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2 results

  • The effect of Zotepine on productive and negative symptoms in schizophrenic patients

  • D.M. Dieterle, M. Ackenheil, H.P. Kapfhammer, F. Müller-Spahn
  • Journal:
    Psychiatry and Psychobiology / Volume 3 / Issue 2 / 1988
    Published online by Cambridge University Press:
    28 April 2020, pp. 125-130
    Print publication:
    1988

  • Zotepine was studied in 15 schizophrenic patients over a period of 28 days with regard to its antipsychotic efficacy, effect on negative schizophrenic symptoms, tolerability and adverse effects. Nine patients received Zotepine in a high dosage of 230 mg/die±52 mg, 6 patients in a low dosage of 168 mg/die ± 18 mg. Two patients receiving the high dosage dropped out after 21 days because of worsening of symptomatology and suicide attempts. Zotepine had rapid antipsychotic effects with sedative properties during the initial days of treatment. Minimal adverse effects and extra-pyramidal motor disturbances as well as dose-dependent positive effects on negative schizophrenie symptoms were found.