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The effect of Zotepine on productive and negative symptoms in schizophrenic patients

Published online by Cambridge University Press:  28 April 2020

D.M. Dieterle ,
M. Ackenheil ,
H.P. Kapfhammer  and
F. Müller-Spahn
D.M. Dieterle
Affiliation:
Psychiatric Hospital of the University of Munich, Nussbaumstr. 7, 8000Munich 2, FRG
M. Ackenheil
Affiliation:
Psychiatric Hospital of the University of Munich, Nussbaumstr. 7, 8000Munich 2, FRG
H.P. Kapfhammer
Affiliation:
State Mental Hospital Regensburg, Universitätsstr., 8400Regensburg, FRG
F. Müller-Spahn
Affiliation:
Psychiatric Hospital of the University of Munich, Nussbaumstr. 7, 8000Munich 2, FRG
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Résumé

Zotepine was studied in 15 schizophrenic patients over a period of 28 days with regard to its antipsychotic efficacy, effect on negative schizophrenic symptoms, tolerability and adverse effects. Nine patients received Zotepine in a high dosage of 230 mg/die±52 mg, 6 patients in a low dosage of 168 mg/die ± 18 mg. Two patients receiving the high dosage dropped out after 21 days because of worsening of symptomatology and suicide attempts. Zotepine had rapid antipsychotic effects with sedative properties during the initial days of treatment. Minimal adverse effects and extra-pyramidal motor disturbances as well as dose-dependent positive effects on negative schizophrenie symptoms were found.

Summary

Summary

La Zotepine a été étudiée chez 15 patients schizophrènes pendant une période de 28 jours pour évaluer son efficacité anti-psychotique, l‘e ffet sur les symptômes négatifs schizophréniques, sa tolérabilité et ses effets indésirables. Neuf patients ont reçu la Zotepine à un dosage élevé de 230 mg/jour ± 52 mg, 6 patients un dosage bas de 168 mg/jour ± 18 mg. Deux patients étaient exclus après 21 jours à cause d‘a ggravations de la symptomatologie et de tentatives de suicide. La Zotepine avait des effets antipsychotiques rapides avec des propriétés sédatives durant les premiers jours du traitement. Des effets secondaires négligeables, desperturbations motrices extrapyram idales ainsi que des effets positifs dose-dépendants sur les symptômes négatifs de la schizophrénie étaient constatés.

Keywords

ZotepineschizophreniaZotepineschizophrénie
Type
Original article
Information
Psychiatry and Psychobiology , Volume 3 , Issue 2 , 1988 , pp. 125 - 130
Copyright
Copyright © European Psychiatric Association 1986

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