We prove that there are no regular algebraic hypersurfaces with non-zero constant mean curvature in the Euclidean space $\mathbb {R}^{n+1},\,\;n\geq 2,$ defined by polynomials of odd degree. Also we prove that the hyperspheres and the round cylinders are the only regular algebraic hypersurfaces with non-zero constant mean curvature in $\mathbb {R}^{n+1}, n\geq 2,$ defined by polynomials of degree less than or equal to three. These results give partial answers to a question raised by Barbosa and do Carmo.