Weeds are among the main limitations on chickpea production in Iran. The efficacy of herbicide treatments including linuron PPI, imazethapyr PPI, PRE, and POST, pendimethalin PPI and POST, bentazon POST, pyridate POST, and oxadiazon POST along with one or two hand weedings were evaluated for weed control and yield response in rain-fed chickpea in Aleshtar, Lorestan, Iran in 2015 and 2016. Wild safflower, threehorn bedstraw, wild mustard, and hoary cress were the predominant weed species in both experimental years. Total weed dry biomass in weedy check plots averaged 187 and 238 g m−2 in 2015 and 2016, respectively, and weed density and biomass were reduced in all treatments compared to the weedy check in both years. Treatments composed of pyridate followed by one hand weeding or imazethapyr POST followed by two hand weedings resulted in the lowest weed biomass. The presence of weeds reduced yield by 74% and 66% in the weedy check plots compared to the weed-free control plots in 2015 and 2016, respectively. Application of oxadiazon, bentazon, and imazethapyr PPI, PRE, and POST resulted in lower chickpea yields. All herbicides tested injured chickpea slightly, with pyridate causing the least injury.