The role of a PFO as a risk factor for ischemic stroke has been established in recent years, particularly for strokes that lack an apparent cause (cryptogenic). Approximately 25% of the general population has a PFO, and it has not been shown to increase the risk of ischemic stroke. On the other hand, the prevalence of PFO is significantly higher in patients with cryptogenic stroke; up to 40% of ischemic cryptogenic strokes have a PFO, suggesting that paradoxical embolism through a PFO may be associated in a number of cryptogenic strokes.We present a 62 year-old female with ischemic stroke and PFO

Over one third of the population develops cancer during their life-time and stroke associated with malignancy accounts for 10% of all hospitalized patients. With and improved survival and better life quality of patients with cancer, cancer related stroke is likely to increase. It is crucial to early diagnose an underlying malignancy to optimize treatment. It is known that a major mechanism is cancer -associated hypercoagulability and over 50% of these strokes are cryptogenic. Cancer related stroke has a high risk of recurrence an improved algorithm of diagnostic-work up and a better evidence regarding secondary prevention are needed