The synthesis of copper citrate complex supported on acid-activated vermiculite was investigated with a view to preparing an efficient, mild, robust and recyclable catalyst for the Biginelli reaction. The new catalyst was characterized by X-ray fluorescence (XRF), infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), X-ray powder diffraction (XRD), and scanning electron microscopy (SEM) coupled with energy dispersive X-ray spectroscopy (EDS). Copper citrate supported over activated vermiculite (AAVrm-Cu2) showed good catalytic activity in the synthesis of 3,4-dihydropyrimidinones. The catalyst can be separated easily from the reaction mixture by filtration and retains its catalytic activity for up to five cycles of reaction with no apparent decrease in yield.
