Several experiments were conducted with Rhipicephalus sanguineus, Dermacentor variabilis and Amblyomma maculatum during which degrees of resistance by rabbits to infestation were quantified. Manifestations of resistance were measured through estimations of “Decreased Tick-Weight Index”, “Decreased Engorgement Period Index” and “Reject Index”. Degree of resistance was evaluated through estimation of Tick Resistance Index. The degree of resistance of rabbits to infestation with each of the three tick species was found to increase with the number of reinfestations. Fully engorged ticks induce the same degree of resistance as partially engorged ones. Nymphal ticks induced higher resistance than larvae, but the resistance conferred by both immature stages was lower than that conferred by adults; previous exposure of rabbits to adults enhanced the degree of resistance against subsequent nymphal or larval infestation. There was cross-resistance between A. maculatum, D. variabilis and R. sanguineus. Resistance induced in rabbits waned with time; rabbits became non-resistant to ticks 12 weeks after the last infestation. Resistance to tick infestation was transferred to rabbits through passive transference of serum from resistant animals. The importance of these observations to the epidemiology of field infestation of animals with ticks is discussed.