The COVID-19 pandemic has affected working women’s well-being in different ways due to contrasting national responses. This article focuses on the specific context of Singapore, which implemented differentiated rules for workers: essential workers continued to report to workplaces, while non-essential workers were required to work from home. This policy had far-reaching implications for working women, who are more likely than husbands to juggle paid work and household duties. The article uses longitudinal data collected in 2018 and during the pandemic in 2020, specifically during Singapore’s lockdown period, to measure changes in 287 working women’s self-reported levels of stress, fatigue, and quality of interpersonal relationships by essential worker status. While all workers were affected by the pandemic, female essential workers were more likely than their non-essential peers to report declines in stress levels from 2018 to 2020, and less likely to report changes in spousal relationships, both positive and negative. Findings suggest that the differences were driven by exposure to quarantine conditions faced by non-essential workers. Our results highlight the importance of policies supporting frontline workers and more gender-equitable labour market policies to support married women juggling the twin demands of employment and household responsibilities.