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The historical backdrop for the role of microscopy in the development of human knowledge is reviewed. Atomic-scale investigations are a logical step in a natural progression of increasingly more powerful microscopies. A brief outline of the concept of atomic-scale analytical tomography (ASAT) is given, and its implications for science and technology are anticipated. The intersection of ASAT with advanced computational materials engineering is explored. The chapter concludes with a look toward a future where ASAT will become common.
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