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The Accelerating COVID-19 Therapeutic Interventions and Vaccines Therapeutic-Clinical Working Group members gathered critical recommendations in follow-up to lessons learned manuscripts released earlier in the COVID-19 pandemic. Lessons around agent prioritization, preclinical therapeutics testing, master protocol design and implementation, drug manufacturing and supply, data sharing, and public–private partnership value are shared to inform responses to future pandemics.
What makes diplomatic negotiation different from other negotiations is that it takes place between or among nation-states through their representatives, and the stakes are usually higher than those in a domestic context. In addition, while other types of negotiation tend to be mostly transactional, negotiating in diplomacy cannot be isolated from the overall relationship with the other party. A truly successful diplomatic negotiation is one that not only resolves an immediate problem, but ensures that the state of relations with the other side will serve one’s interests in the long run. That does not mean that ties must necessarily be close or friendly, as long as they are civil and respectful, and the countries can work together in the future. Another feature of negotiation that is essential in diplomacy is its ability to build a basis for empathy. It helps to convey one’s own motivations and interests directly, which can reduce misunderstanding, and it provides insight into the other side’s motivations and perceptions.
In the face of a rapidly emerging pandemic, there needs to be a concerted and organized response so that the pandemic can be stopped or slowed and patients can be accurately diagnosed and treated. As we learned with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there was no prescribed roadmap to follow, leaving scientists and clinicians to plan and respond in real time. Although the efforts were heroic in nature, some decisions (if they could be made again) would have been different. In this chapter, we address the lessons learned from the individuals who were on the battlefield in their area of expertise as they chartered their own path. We capture and record the activities that took place so that, going forward, there will be an extensive pandemic response roadmap indicating the activities of this pandemic (including their chronology and duration) for future generations to use as a guiding document to build upon.
Bob Medearis, Roger Smith, and Bill Biggerstaff founded Silicon Valley Bank in 1983. Smith ran the Bank as a startup business in the first decade. Subsequent CEO John Dean restructured the Bank and Ken Wilcox redirected the Bank with a central focus on exclusively serving the tech community. Greg Becker accelerated the Bank, connecting its past to the future. The bank’s assets grew at a fast pace during the pandemic. Becker tripled the size of the bank between 2019 and 2022.
Edited by
Richard Williams, University of South Wales,Verity Kemp, Independent Health Emergency Planning Consultant,Keith Porter, University of Birmingham,Tim Healing, Worshipful Society of Apothecaries of London,John Drury, University of Sussex
The survival rate of 90% among wounded UK troops in Afghanistan (2004–2014) was the highest in the history of warfare. Foremost among these were severely disabled amputees, who emerged as an unexpected cohort of survivors of critical injuries. Soldiers who would have died from injuries in earlier wars were kept alive thanks to fellow soldiers highly trained in trauma medicine, paramedics who accompanied the helicopters, and the trauma care that the troops later received in hospital. We discuss our UK experience of learning from warfare, what made a difference, and how new knowledge could be used to improve physical injury and mental health related to trauma care in the UK. For the sake and sacrifice of our fallen and injured soldiers and for the benefit of our future NHS patients, an obligation rests with the NHS to allow the lessons learned from past conflicts to benefit the injured of the future.
Those who responded to the COVID-19 pandemic have now had the opportunity to reflect on lessons learned, and in this science and data-rich book, those reflections are presented as a behind-the-scenes chronology of events and discoveries that occurred in COVID-19's wake. Offering a rubric for a future pandemic response, each chapter is written by experts, with their unique perspectives, experience, and learnings woven into visual roadmaps throughout the book. These roadmaps serve as a scaffolding upon which future healthcare leaders can build when creating, implementing and executing operational strategies in the face of future infectious disease outbreaks. Written for both lay and scientific audiences and featuring case studies which give clinical insight into the unique bond between COVID patients, their loved ones and their healthcare providers, this important book allows readers to leverage the knowledge of experts to improve the outcomes of future pandemics.
This piece recounts the efforts by NGO Sign of Hope (SoH) to rectify human rights violations in South Sudan, which manifested themselves as drinking water pollution by the oil industry. Committed to exposing and remediating this water contamination, SoH was able to prompt the automobile company Daimler’s CSR to engage in extended dialogue with the oil industry stakeholders in Unity State. Despite a tactful use of various methods ranging from cooperation to confrontation, SoH’s campaign did not lead the oil producers to reverse the harm inflicted on the people of Unity State. When SoH tried to hold these companies accountable, SoH had the impression that it was hitting an elastic wall. This piece identifies lessons which may help to counter corporate human rights violations and compensate for the weakness of CSR in fragile states and in the face of corporate irresponsibility.
The University of Illinois at Chicago (UIC), along with many academic institutions worldwide, made significant efforts to address the many challenges presented during the COVID-19 pandemic by developing clinical staging and predictive models. Data from patients with a clinical encounter at UIC from July 1, 2019 to March 30, 2022 were abstracted from the electronic health record and stored in the UIC Center for Clinical and Translational Science Clinical Research Data Warehouse, prior to data analysis. While we saw some success, there were many failures along the way. For this paper, we wanted to discuss some of these obstacles and many of the lessons learned from the journey.
Methods:
Principle investigators, research staff, and other project team members were invited to complete an anonymous Qualtrics survey to reflect on the project. The survey included open-ended questions centering on participants’ opinions about the project, including whether project goals were met, project successes, project failures, and areas that could have been improved. We then identified themes among the results.
Results:
Nine project team members (out of 30 members contacted) completed the survey. The responders were anonymous. The survey responses were grouped into four key themes: Collaboration, Infrastructure, Data Acquisition/Validation, and Model Building.
Conclusion:
Through our COVID-19 research efforts, the team learned about our strengths and deficiencies. We continue to work to improve our research and data translation capabilities.
This chapter starts with a discussion of the role played by verifiers in peace. We discuss some of the many types of verifiers, and how those whose roles are outside the formal political process can help to construct peace. Many of these have scientific or investigatory roles whose work informs the state of the world. There are interesting models in aviation, including not only the National Transportation Safety Board (NTSB) but also a variety of others including institutions dedicated to telemetry analysis and near miss analysis. We examine each and suggest how a cyber equivalent could contribute to our understanding of the state of the world, and in doing so, support peace.
Having systematically reviewed a comprehensive range of management measures across a wide range of rivers this chapter provides an overview of lessons learned to inform future management strategies. Key lessons are elucidated that relates to (i) urban flood management, (ii) the role of floodplain sedimentology in the design of effective hydraulic infrastructure (iii), the unintended geomorphic consequences of hydraulic engineering (iv), the palimpsest of floodplain management (v), dam removal and reservoir management and (vi), linkages between geodiversity and biodiversity. These lessons pertain to three main fluvial environments, including fluvial adjustment of channels, embanked floodplains, and flood basins and deltas. The study concludes by discussing reasons for concern and reasons for optimism as regards future management of lowland river environments.
This chapter addresses many other aspects that are affected in addition to the direct communication links, when introducing Automotive Ethernet into the vehicle architecture. It describes how the system development process is affected, the software design, the networking architecture, test and qualification, as well as functional safety. Last but not least it shares some important lessons learned.
COVID-19 altered research in Clinical and Translational Science Award (CTSA) hubs in an unprecedented manner, leading to adjustments for COVID-19 research.
Methods:
CTSA members volunteered to conduct a review on the impact of CTSA network on COVID-19 pandemic with the assistance from NIH survey team in October 2020. The survey questions included the involvement of CTSAs in decision-making concerning the prioritization of COVID-19 studies. Descriptive and statistical analyses were conducted to analyze the survey data.
Results:
60 of the 64 CTSAs completed the survey. Most CTSAs lacked preparedness but promptly responded to the pandemic. Early disruption of research triggered, enhanced CTSA engagement, creation of dedicated research areas and triage for prioritization of COVID-19 studies. CTSAs involvement in decision-making were 16.75 times more likely to create dedicated diagnostic laboratories (95% confidence interval [CI] = 2.17–129.39; P < 0.01). Likewise, institutions with internal funding were 3.88 times more likely to establish COVID-19 dedicated research (95% CI = 1.12–13.40; P < 0.05). CTSAs were instrumental in securing funds and facilitating establishment of laboratory/clinical spaces for COVID-19 research. Workflow was modified to support contracting and IRB review at most institutions with CTSAs. To mitigate chaos generated by competing clinical trials, central feasibility committees were often formed for orderly review/prioritization.
Conclusions:
The lessons learned from the COVID-19 pandemic emphasize the pivotal role of CTSAs in prioritizing studies and establishing the necessary research infrastructure, and the importance of prompt and flexible research leadership with decision-making capacity to manage future pandemics.
Learn about the latest developments in Automotive Ethernet technology and implementation with this fully revised third edition. Including 20% new material and greater technical depth, coverage is expanded to include detailed explanations of the new PHY technologies 10BASE-T1S (including multidrop) and 2.5, 5, and 10GBASE-T1, discussion of EMC interference models, and description of the new TSN standards for automotive use. Featuring details of security concepts, an overview of power saving possibilities with Automotive Ethernet, and explanation of functional safety in the context of Automotive Ethernet. Additionally provides an overview of test strategies and main lessons learned. Industry pioneers share the technical and non-technical decisions that have led to the success of Automotive Ethernet, covering everything from electromagnetic requirements and physical layer technologies, QoS, and the use of VLANs, IP and service discovery, to network architecture and testing. The guide for engineers, technical managers and researchers designing components for in-car electronics, and those interested in the strategy of introducing a new technology.
By way of conclusion, the final chapter brings together the lessons learned and the lessons remaining concerning approaches and frameworks for HCI research. The scope of the lessons learned and the lessons remaining include approaches and frameworks for HCI research, approaches to HCI research, frameworks for HCI research, specific frameworks for HCI research, general approach and General Framework for HCI research, validating the general approach and the General Framework for HCI research, assessing the General Framework against other HCI frameworks, assessing the General Framework against HCI theories, methodological components for the General Framework, and case studies for the General Framework. The conclusion takes the form of a proposal for an HCI research programme, which builds on the lessons learned to formulate the lessons remaining. Together they constitute the research programme.
This research textbook, designed for young Human-Computer Interaction (HCI) researchers beginning their careers, surveys the research models and methods in use today and offers a general framework to bring together the disparate concepts. HCI spans many disciplines and professions, including information science, applied psychology, computer science, informatics, software engineering and social science making it difficult for newcomers to get a good overview of the field and the available approaches. The book's rigorous 'approach-and-framework' response is to the challenge of retaining growth and diversification in HCI research by building up a general framework from approaches for Innovation, Art, Craft, Applied, Science and Engineering. This general framework is compared with other HCI frameworks and theories for completeness and coherence, all within a historical perspective of dissemination success. Readers can use this as a model to design and assess their own research frameworks and theories against those reported in the literature.
The study concludes that the case of Libya fully exposed the potential as well as the complexities inherent in the responsibility to protect. The political-moral imperative encapsulated by the principle played a decisive role in the Security Council’s decision to authorize the use of force in order to protect civilians – which most likely averted mass atrocities. However, the responsibility to protect provided a highly fragile basis for military enforcement action without host state consent – by leaving essential questions regarding the legitimacy of international authority and the relation of international actors to local actors unresolved. The chapter examines the implications of the Libyan case for the normative development of the responsibility to protect. Subsequently, a number of conclusions are drawn regarding specific aspects of the principle. These concern the concept of "the international community"; collective security arrangements; questions of neutrality and impartiality; and consistency between the intervention and pre- and post-intervention politics.
The 2011 crisis in Libya represents the first case in which the international community invoked 'the Responsibility to Protect' principle, adopted in 2005 by UN member states, to justify coercive measures including sanctions and the use of military force. In this study, Karin Wester meticulously reconstructs and analyzes the evolution of the Libyan crisis, the international community's response, and the manner in which the 'Responsibility to Protect' was applied. Drawing on a wide variety of primary sources including in-depth interviews with politicians and diplomats, this comprehensive account of the 2011 intervention in Libya redresses popular narratives asserting that the intervention was driven primarily by western (neo-colonial) interests or by a desire for regime change. Instead, Wester reveals how the 'Responsibility to Protect' principle was realized to a considerable extent, but also how it provided a highly fragile basis for military enforcement action. Incorporating perspectives from international law, political science and history, this is a compelling and thought-provoking examination of the real-world application of a principle that is deeply rooted in history but presents daunting challenges in implementation.
The response to the novel coronavirus outbreak in China suggests that many of the lessons from the 2003 SARS epidemic have been implemented and the response improved as a consequence. Nevertheless some questions remain and not all lessons have been successful. The national and international response demonstrates the complex link between public health, science and politics when an outbreak threatens to impact on global economies and reputations. The unprecedented measures implemented in China are a bold attempt to control the outbreak – we need to understand their effectiveness to balance costs and benefits for similar events in the future.