Methyl bromide (MeBr), classified as a Class I ozone-depleting substance, has been banned for ordinary agricultural uses. Weed control in commercial bell pepper production is complicated by the ban on MeBr and the lack of other available and effective soil fumigants. A field study was conducted to evaluate the effectiveness of allyl isothiocyanate (ITC) and metam sodium (methyl ITC generator) as MeBr alternatives for control of Palmer amaranth, large crabgrass, and yellow nutsedge; and for increasing marketable yields in low-density polyethylene (LDPE) –mulched bell pepper. Allyl ITC was applied at 450, 600, and 750 kg ha−1; metam sodium was applied at 180, 270, and 360 kg ha−1; and MeBr plus chloropicrin (67% and 33%, respectively) was applied at 390 kg ha−1. Allyl ITC and metam sodium did not injure bell pepper. Allyl ITC at 750 kg ha−1 or metam sodium at 360 kg ha−1 controlled Palmer amaranth (≥ 83%), large crabgrass (≥ 78%), and yellow nutsedge (≥ 80%) comparably to MeBr. Yellow nutsedge tuber density was ≤ 84 tubers m−2 in plots treated with the highest rate of allyl ITC and metam sodium and was comparable to the tuber density in MeBr-treated plots. Although allyl ITC at 750 kg ha−1 controlled weeds comparable to MeBr, total marketable bell pepper yield with allyl ITC was lower than the yield with MeBr. Conversely, total marketable bell pepper yield with the highest rate of metam sodium (53.5 ton ha−1) was equivalent to the yield (62.5 ton ha−1) in plots treated with MeBr. In conclusion, metam sodium at 360 kg ha−1 is an effective MeBr alternative for weed control in LDPE–mulched bell pepper.