Although it lacked a significant domestic market for internationally trafficked drugs, East Germany emerged as an important corridor for narcotics smugglers in the 1970s due to its position between supply countries in Asia and consumer countries in the West. The unique geography of West Berlin created a large market of consumers surrounded by East German territory, forcing traffickers to pass through the GDR border. Efforts by officials in both Germanys and the United States to cooperate on the problem of narcotics trafficking revealed conflicts between the geography of the Cold War—where the GDR border was the front line in the ideological conflict between East and West—and the international drug prohibition system, which sought global interstate collaboration in the name of a “universal international society,” against the common threat of crime. As Cold War tensions declined in the 1980s, border enforcement cooperation between East and West became increasingly viable as both sides reoriented toward the view that Europe had to defend itself from the threats posed by mobilities of those in the global south.

This article pits two conceptions of modernity—that of the Marxist humanist Marshall Berman and the ANT (Actor-Network Theory) sociologist Bruno Latour—against each other, exploring the implications of each for postcolonial and world literary criticism. The article begins by explaining “modernity” in the terms of both theorists, focusing on the “split” between subject and object, text and world. It then identifies a wider Latourian turn in postcolonial and world literary studies that has emerged in response to the prescriptively structural approaches of groups such as the WReC. In response, the article offers in turn a Latourian reading and then a structural critique of the Colombian novelist Juan Gabriel Vásquez’s fifth novel, The Sound of Things Falling (2011, trans. 2013), probing their possibilities and limitations. In conclusion, it suggests Berman’s more expansive definition of modernist practice as one way in which postcolonial and world literary criticism might more effectively mediate between structural critique and close reading.

Introduction: Despite an overall decline in opioid prescriptions in Canada, healthcare visits, hospitalizations, and deaths due to opioid-related harms continue to rise for children. Clinicians urgently require high quality synthesized evidence to inform personalized decisions regarding opioid use for children. The objective of this systematic review was to examine the association between short-term therapeutic exposure to opioids and development of opioid use disorder. Methods: A medical librarian conducted a comprehensive search of 10 databases from inception to May 2019. Two authors independently assessed studies for inclusion. Studies were eligible if they reported primary research in English or French, and study participants had short (<14 days) or non-specific duration of therapeutic exposure to opioids before age 18 years. Primary outcome was the development of an opioid use disorder; secondary outcomes included opioid addiction, dependence, misuse, and abuse. Data extraction involved two independent reviewers utilizing a standardized form. Methodological quality was assessed using the NIH tools for observational studies. Results are described narratively. Results: The search identified 4,072 unique citations; 82 were selected for review, and 17 were included (3 retrospective cohort, 4 prospective cohort, and 10 cross-sectional). All studies took place in the USA. A total of 1,562,503 participants were analyzed. Nine studies were administered in schools, 3 used administrative data. While most settings were non-specific, 1 study examined opioid use in dentistry, 1 in trauma, and 1 in organized sports. One comparative study showed an association between short-term therapeutic use and opioid misuse. Two studies showed opioid related adverse events (e.g., overdose) among cohorts exposed to short-term use. The remaining 14 studies did not specify duration of exposure; therefore, confirming whether misuse was due to short-term therapeutic exposure was not possible. Conclusion: A small number of studies in this review suggest an association between short-term opioid use and opioid misuse; however, further analysis is underway with consideration of methodological limitations of the individual studies (final results pending). Careful consideration of the risk and benefits of short-term opioid use should be undertaken prior to prescribing opioids. PROSPERO Registration Number: 122681.

The use of a wide range of narcotic drugs in antiquity has been widely documented, although archaeologists have sometimes been too credulous of apparently scientific data, and have failed to appreciate the post-excavation histories of artefacts, including mummies. This paper examines the discovery of tobacco in the mummy of Rameses II, provides an alternative model for its origin, as a 19th-century insecticide used in conservation, and throws doubt upon the evidence for both cannabis and cocaine in ancient Egypt.

Background and objective To compare the effects on cardiovascular changes induced by tracheal intubation when small doses of either remifentanil or sufentanil are used in the presence of midazolam.

Methods Thirty normotensive, ASA physical status I–II patients, receiving general anaesthesia for major abdominal surgery, received an intravenous midazolam premedication (0.05 mg kg−1) 10 min before induction. They were randomly allocated to receive in a double-blind fashion an intravenous bolusofeither(a)remifentanil given as a bolus dose 1 μg kg−1 (n = 15), or else (b) sufentanil 0.1 μg kg−1 infused over 60s (n = 15). In each instance this loading dose was followed by a continuous intravenous infusion (0.1 μg kg−1 min−1 or 0.01 μg kg−1 min−1 of remifentanil or sufentanil, respectively). General anaesthesia was induced with propofol (2 mg kg−1), followed by atracurium besilate (0.5 mg kg−1) to facilitate tracheal intubation. Following intubation, the lungs were mechanically ventilated with a 60% nitrous oxide in oxygen mixture and a 1% inspired sevoflurane.

Results Arterial pressure and heart rate were recorded before induction of anaesthesia (baseline), immediately before intubation, immediately after tracheal intubation and every minute for the first five minutes thereafter. No differences in systolic and diastolic arterial pressures were observed between the two groups. At the end of the study period, systolic and diastolic pressures slightly decreased from preinduction values in both groups. Four patients in the remifentanil group (26%) and five patients in sufentanil group (33%) showed at least one systolic pressure value <90 mm Hg during the study period (P = not significant); however, the observed decreases in systolic pressure were transient and did not require treatment. Heart rate values were not affected by tracheal intubation in either group.

Conclusions In healthy normotensive patients without cardiovascular disease the use of a relatively small dose of either remifentanil or sufentanil after standard midazolam premedication results in a similar and clinically acceptable effectiveness in blunting the cardiovascular changes induced by tracheal intubation.