Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

2 results

  • Neurodevelopment outcomes in the first 5 years of the life of children with transposition of the great arteries surgically corrected in the neonatal period: systematic review and meta-analysis

  • Catarina Soares, Rafael José Vieira, Sandra Costa, Rita Moita, Mariana Andrade, Hercília Guimarães
  • Journal:
    Cardiology in the Young / Volume 33 / Issue 12 / December 2023
    Published online by Cambridge University Press:
    15 November 2023, pp. 2471-2480
    • Article
      • You have access
    • PDF
    • HTML
    • Export citation

  • Congenital Heart Defects are the most common abnormalities at birth, resulting in many short- and long-term consequences.

    Objectives:

    In patients with transposition of the great arteries, surgical correction may achieve definitive treatment, so a thorough knowledge of the long-term outcomes, particularly neurodevelopment outcomes, is essential. Therefore, we conducted a systematic review and meta-analysis to study the neurodevelopment outcomes in the first 5 years of the life of children submitted to corrective surgery for transposition of the great arteries in the neonatal period.

    Methods:

    A total of 17 studies from 18 reports were included, assessing 809 individuals with surgically corrected transposition of the great arteries. The neurodevelopmental outcomes were assessed with the Bayley Scales of Infant and Toddler Development (BSID) and the Wechsler Intelligence Scale for Children (WISC).

    Results:

    Mean Mental Development Index (MDI) and Psychomotor Development Index (PDI) were within the average values from 1 to 3 years of age, although the proportion of children scoring more than 1 standard deviation below the mean in PDI, MDI, motor, and language composite scores was significantly higher than in the general population. From 4 to 5 years, mean full-scale global intelligence quotient (IQ), verbal IQ, and performance IQ scores did not differ significantly from the general population.

    Conclusion:

    This study revealed neurodevelopment scores within the normal range at 5 years of age in children submitted to corrective surgery for transposition of the great arteries in the neonatal period. However, these early outcomes may not adequately predict long-term outcomes. Further studies are needed to identify specific risk factors and early markers of later impairment to guide the establishment of early interventions.

  • 15 - Communicating with patients and the public about environmental exposures and reproductive risk

  • Edited by Tracey J. Woodruff, University of California, San Francisco, Sarah J. Janssen, University of California, San Francisco, Louis J. Guillette, Jr, University of Florida, Linda C. Giudice, University of California, San Francisco
  • Book:
    Environmental Impacts on Reproductive Health and Fertility
    Published online:
    23 February 2010
    Print publication:
    28 January 2010, pp -

  • Summary

    This chapter discusses the key events occurring at different stages of development in the normal human male and how this impacts the reproductive function in adulthood. Development of the normal male reproductive system can be divided into five periods: fetal, neonatal, infancy/childhood, puberty, adulthood. Normal hormonal functioning of the fetal testis is essential for masculinization and for development of a male reproductive system. In neonatal male and female babies there is activation of the hypothalamic-pituitary axis and consequent increase in circulating levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). During the neonatal period, Sertoli cells continue to proliferate and this is arguably the most important period in life in terms of the magnitude of increase in Sertoli cell numbers. Sertoli cells start expressing androgen receptor (AR) at the onset of puberty and this is considered one sign of maturation of these cells, as they terminally differentiate and cease proliferating.