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1 results

  • Prevalence of aspirin resistance by thromboelastography plus platelet mapping in children with CHD: a single-centre experience

  • Fernando M. Berganza, Cesar Gonzalez de Alba, Alexander C. Egbe, Sergio Bartakian, John Brownlee
  • Journal:
    Cardiology in the Young / Volume 29 / Issue 1 / January 2019
    Published online by Cambridge University Press:
    03 December 2018, pp. 24-29
  • Rationale

    Aspirin resistance has been reported in up to 80% of children with cardiovascular defects undergoing surgery. Because of a patient who had embolic stroke while on therapeutic aspirin dose but in whom aspirin resistance was present on his thromboelastography platelet mapping, we chose to obtain thromboelastography platelet mapping on cardiac patients on aspirin to assess their risk.

    Objectives

    This study evaluates aspirin resistance noted in these patients and their characteristics.

    Methods and results

    This is a retrospective study of 25 patients taking aspirin for a month at therapeutic dose. In total, 11 female patients were enrolled. Ages in all subjects were 5 months to 27 years. A total of 19 patients had a Fontan surgery. Three had a cavopulomanary anastomosis, one had a hybrid procedure, and two had coronary anomalies. Compliance was assessed at the time of the clinic visit. Aspirin resistance was defined as platelet inhibition below 50%. Variables evaluated were level of platelet inhibition, age, body mass index, and gender.