We prove that either the images of the mapping class groups by quantum representations are not isomorphic to higher rank lattices or else the kernels have a large number of normal generators. Further, we show that the images of the mapping class groups have non-trivial 2-cohomology, at least for small levels. For this purpose, we considered a series of quasi-homomorphisms on mapping class groups extending the previous work of Barge and Ghys (Math. Ann. 294 (1992), 235–265) and of Gambaudo and Ghys (Bull. Soc. Math. France 133(4) (2005), 541–579). These quasi-homomorphisms are pull-backs of the Dupont–Guichardet–Wigner quasi-homomorphisms on pseudo-unitary groups along quantum representations.