Climate change negatively impacts rice productivity in different parts of Africa. As a matter of necessity, farmers must respond to changing the climate by choosing adaptation strategies that increase their productivities. Incidentally, studies that documented the impact of climate change adaptation actions of farmers on rice productivity are few. This study therefore analyzed the impact of climate change adaptation decisions of farmers on the profitability of rice production using cross-sectional data gathered from 240 rice farmers selected from Ebonyi State, an important rice-producing State in Nigeria, Africa's most populous country. Using descriptive statistics, multivariate probit regression, instrumental variable regression and endogenous treatment effect model, the study revealed that the common adaptation actions of rice farmers involved adoption of minimum tillage, bond and drainage, fertilizer, crop diversification, livelihood diversification, improved rice varieties, pesticide, nursery, and adjusting planting and harvesting dates. The study found several significant interactions between the choice of climate change adaptation actions and socio-economic, farm, institutional and location characteristics of rice farmers. The result further revealed that multiple adaptation decisions of farmers significantly increased returns to scale and profit of rice production. The study concludes that adaptation decisions are effective in increasing the profitability and returns to scale of rice production in the area and other regions with similar geographical, meteorological and socio-economic contexts.