A study was conducted at the Louisiana State University Agricultural Center’s H. Rouse Caffey Rice Research Station in 2017 and 2018 to evaluate the interaction between a prepackage mixture of clomazone plus pendimethalin applied at 0, 760, 1,145, or 1,540 g ai ha−1 mixed with propanil at 0, 1,120, 2,240, or 4,485 g ai ha−1. A synergistic response occurred when barnyardgrass was treated with all rates of clomazone plus pendimethalin mixed with either rate of propanil evaluated at 56 d after treatment (DAT). Unlike barnyardgrass, an antagonistic response occurred in yellow nutsedge used as a control when treated with 760 and 1,540 g ha−1 of clomazone plus pendimethalin mixed with 1,120 or 22,40 g ha−1 of propanil at 28 DAT; however, 1,145 g ha−1 of clomazone plus pendimethalin mixed with 4,485 g ha−1 of propanil resulted in a neutral interaction. At 28 DAT, rice flatsedge treated with all herbicide mixtures resulted in neutral interactions. The synergism of clomazone plus pendimethalin applied at 1,540 g ha−1 mixed with propanil applied at 2,240 or 4,485 g ha−1 to control barnyardgrass resulted in an increased rough rice yield compared with 760 or 1,145 g ha−1 of clomazone plus pendimethalin mixed with propanil applied at 1,120 or 2,240 g ha−1. These results indicate that if barnyardgrass and rice flatsedge are present in a rice field the prepackage mixture of clomazone plus pendimethalin mixed with propanil can be an option for growers. However, if yellow nutsedge infest the area other herbicides may be needed.