Field studies conducted from 2005 to 2007 in Kansas compared the effects of KIH-485 and flufenacet to acetochlor and s-metolachlor applied PRE in grain sorghum. All treatments were combined with 1.12 kg/ha of atrazine for broadleaf weed control. KIH-485 and flufenacet, each at one time (1×) and two times (2×) the labeled rates, controlled large crabgrass 55 to 76% in 2005 and 94% or more in 2006 and 2007. In 2005, all herbicides controlled shattercane less than 20%, and only KIH-485 at the 2× rate controlled shattercane more than 70% in 2006 and 2007. Averaged over herbicides, green foxtail was controlled 98% in 2005, 77% in 2006, and 79% in 2007. Most herbicides controlled foxtail 86% or more when averaged over experiments, however, s-metolachlor at 1×, flufenacet at either rate, or atrazine alone did not. Sorghum was not stunted with KIH-485 or flufenacet in two of seven experiments. However, sorghum growth was reduced 23 to 54% with the 2× rates of KIH-485, flufenacet, or acetochlor in four experiments. Compared to the weed free control, sorghum stand establishment was reduced 18% with the 2× rate of flufenacet at Colby in 2006. At Hays in 2005, stand reductions occurred with acetochlor or KIH-485 at the 2× rates and either rate of flufenacet. Averaged over experiments, grain yields were reduced 9 and 10% with KIH-485 and flufenacet at the 2× rates, respectively. Where precipitation was greatest during the 2 wk following herbicide application, weed control was the best with these herbicides, but sorghum injury was also greatest.