Field studies were conducted in 1995 and 1996 at three locations in North Carolina to evaluate weed control and soybean injury with postemergence (POST) treatments of cloransulam-methyl alone or in tank-mixture with acifluorfen, fomesafen, or lactofen compared with a commercial standard of acifluorfen plus bentazon. Soybean injury was 2 to 3% 7 d after treatment with cloransulam-methyl applied alone and 11 to 46% when applied with fomesafen, lactofen, acifluorfen, or acifluorfen plus bentazon. Cloransulam-methyl applied alone controlled 95% of entireleaf morningglory and ivyleaf morningglory. Control was not increased by the addition of acifluorfen, fomesafen, or lactofen. Cloransulam-methyl improved the control of common lambsquarters to at least 81% compared with dimethenamid applied preemergence alone (69% control). All diphenyl ether herbicide treatments controlled common lambsquarters at least 91%. Prickly sida control by cloransulam-methyl ranged from 14 to 73% 8 wk after treatment. Control of prickly sida was varied by diphenyl ether herbicides (73 to 100% control). Tank-mixtures of cloransulam-methyl + fomesafen and cloransulam-methyl + acifluorfen increased the control of prickly sida over either herbicide applied alone. Soybean yield was greater for all tank-mixtures than for any diphenyl ether herbicide or for cloransulam-methyl treatment applied alone. But only the acifluorfen + cloransulam-methyl treatment had higher economic returns than the cloransulam-methyl treatment alone. All other POST systems, with the exception of lactofen applied alone, had similar economic returns. Tank-mixtures of cloransulam-methyl and diphenyl ether herbicides increased the spectrum of control and soybean yield compared with these herbicides applied alone.