Field experiments were conducted on eight weed species to determine if chlorimuron, fomesafen, imazethapyr, or sulfentrazone at two rates (labeled and one-half the labeled rate) were complementary tank mixtures with glyphosate at 210 and 420 g ai ha−1. Laboratory experiments were conducted on barnyardgrass, pitted morningglory, Palmer amaranth, and velvetleaf using radiolabeled glyphosate, chlorimuron, and imazethapyr to determine the absorption and translocation pattern of these herbicides applied alone and in combination. In the field, glyphosate plus chlorimuron tank mixtures were generally additive. Adding chlorimuron did not decrease absorption or translocation of 14C-glyphosate by barnyardgrass, pitted morningglory, or velvetleaf. Adding glyphosate increased absorption of 14C-chlorimuron by Palmer amaranth and velvetleaf. All four fomesafen plus glyphosate rate combinations were antagonistic to goosegrass, sicklepod, Palmer amaranth, and velvetleaf, and three of the four were antagonistic to barnyardgrass and entireleaf morningglory. Fomesafen decreased absorption and translocation of 14C-glyphosate in barnyardgrass, pitted morningglory, and velvetleaf. Ninety percent of glyphosate plus imazethapyr combinations were additive or synergistic, with all rate combinations synergistic for pitted morningglory. Adding glyphosate to imazethapyr increased absorption of 14C-imazethapyr by Palmer amaranth and velvetleaf. Glyphosate plus sulfentrazone tank mixtures were antagonistic at all rate combinations for barnyardgrass and Palmer amaranth and at three of the four combinations for goosegrass and entireleaf morningglory, indicating that these herbicides are not complementary in tank mixtures.