Yellow toadflax (Linaria vulgaris P. Mill.) infestations in North Dakota increased 300-fold from 1997 to 2011, when the plant was added to the state noxious weed list. Long-term control of other invasive species had included biological control agents, but no effective agents for yellow toadflax had been identified, so a control program using herbicides was needed. The objective was to shift from short-term control with picloram applied in the fall at maximum allowed rates to long-term management with minimal nontarget species impact with an adaptive management approach. Yellow toadflax control was increased from an average of 64% with picloram at 1,120 g ha−1 alone 12 mo after treatment (MAT) to over 90% when applied with diflufenzopyr while the picloram rate was reduced 50%. Yellow toadflax control with aminocyclopyrachlor applied at 140 g ha−1 ranged from 91 to 49% 12 MAT when applied in June or September, respectively. In contrast, yellow toadflax control with picloram plus dicamba plus diflufenzopyr averaged > 90% regardless of application date during the growing season. Land managers now have at least two options for long-term yellow toadflax control with a wide window of application timing. The goal of replacing a single high-use–rate herbicide treatment was met but both picloram and aminocyclopyrachlor can injure many desirable forbs. However, application timing can now be adjusted to have the least impact on nontarget species. The adaptive development program led to a 58% reduction in yellow toadflax infestations in North Dakota by 2014.