With the declaration of the coronavirus disease 2019 (COVID-19) pandemic in Nigeria in 2020, the Nigeria Governors’ Forum (NGF) instigated a collaboration with MTN Nigeria to develop data-driven insights, using mobile big data (MBD) and other data sources, to shape the planning and response to the pandemic. First, a model was developed to predict the worst-case scenario for infections in each state. This was used to support state-level health committees to make local resource planning decisions. Next, as containment interventions resulted in subsistence/daily paid workers losing their income and ability to buy essential food supplies, NGF and MTN agreed a second phase of activity, to develop insights to understand the population clusters at greatest socioeconomic risk from the impact of the pandemic. This insight was used to promote available financial relief to the economically vulnerable population clusters in Lagos state via the HelpNow crowdfunding initiative. This article discusses how anonymized and aggregated mobile network data (MBD), combined with other data sources, were used to create valuable insights and inform the government, and private business, response to the pandemic in Nigeria. Finally, we discuss lessons learnt. Firstly, how a collaboration with, and support from, the regulator enabled MTN to deliver critical insights at a national scale. Secondly, how the Nigeria Data Protection Regulation and the GSMA COVID-19 Privacy Guidelines provided an initial framework to open the discussion and define the approach. Thirdly, why stakeholder management is critical to the understanding, and application, of insights. Fourthly, how existing relationships ease new project collaborations. Finally, how MTN is developing future preparedness by creating a team that is focused on developing data-driven insights for social good.