Thomas of Edessa (d. c. 540), author of Explanations of the Nativity and of Epiphany, flourished as a teacher at the School of Nisibis in Sasanid Persia. By analysing his understanding of salvation history, exegesis and the idea of the human being as ‘bond of creation’, this article shows how Thomas took up and popularised concepts central to the theology of Theodore of Mopsuestia. The article posits that the Nisibene school theology of Thomas and others constituted – alongside liturgy, canonical decrees and biblical commentaries – one of the principal avenues by which Theodore's theology was transmitted to the Church of the East.