This paper presents a test for determining significance of differences between means of samples which are drawn from positively skewed populations, more specifically, those having a Pearson Type III distribution function. The quantity 2npxg/xp (where p equals the mean squared divided by the variance and n is the number of cases in the sample), which distributes itself as Chi Square for 2np degrees of freedom, may be referred to the tables of Chi Square for testing hypotheses about the value of the true mean. For two independent samples, the larger mean divided by the smaller mean, which distributes itself as F for 2n1p1 and 2n2p2 degrees of freedom, may be referred to the F distribution tables for testing significance of difference between means. The test assumes that the range of possible scores is from zero to infinity. When a lower theoretical score limit (c) exists which is not zero, the quantity (Mean − c) should be used instead of the mean in all calculations.