From its inception, the United States Public Health Service (USPHS) has been expressly areligious, aiming to promote the health of the American people during specific crises such as the COVID-19 pandemic, as well as responding to endemic issues such as heart disease, opioid addiction and obesity. However, some Christian nationalists perceive this areligious advocacy of science as a challenge to the moral authority of Christianity and the Bible. Protests against public health guidelines have utilized religious language to defend what participants see as their civil and God-given rights, deepening the divide between science and religion. Yet historically, public health advocates have built relationships with religious community leaders and employed educational campaigns to bridge this gap. Drawing on an analysis of USPHS history, Christian nationalist ideology and recent COVID-19 protests, this article argues that public health has historically used specific strategies to ensure a more favourable response and compliance, and makes the case that it should do so again.