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What role is attributed to geological knowledge within the broader whole of the Encyclopaedia? Which perspective is adequate to make philosophical sense of geological knowledge? This chapter’s response to these questions consists in a three-step argument. First, for Hegel, geohistory is irrelevant to philosophy but not the particular ways in which geological regularities are determined. Second, it argues that geology is important for Hegel as it develops the emergence of formations and structures that do not have a strict precedent in the domains of mechanical physics and chemistry, even if they arise from them. These formations and structures have a unique unity of composition and appearance, they form a dynamical but stable entity. Hereby geological notions serve to develop a particular notion of instantiation and self-determination that mediates inanimate matter with organic life. Third, it argues that by means of said emergence of formations and structures and their global arrangement, geology provides us with the basic notion of environment that serves as a precondition for the emergence of organic life. Hereby geology for Hegel mediates inorganic matter with the purposiveness of organisms.
Familiarity with chemistry from children’s toy kits leads Weinberg to investigate physics, the subject that underlies all of chemistry. He reads George Gamow’s Mr. Tompkins books, among others. He is admitted to the famous Bronx High School of Science, where he becomes friends with Shelly Glashow and Gary Feinberg, who would also become well-known physicists. He wins a New York state scholarship to Cornell.
Transmission electron microscopy-energy dispersive X-ray analysis (TEM-EDX) represents an effective tool for determining the stoichiometric composition of clay minerals, but the methodology is often hampered by analytical difficulties. Studies of beam-sensitive minerals, such as smectites, are associated with low count intensities and dynamic loss of cations (e.g. K+, Na+, and Al3+), which can lead to erroneous quantifications of composition. After exploring how to minimize cation migration by reducing the beam current density to <5 pA cm–2, the most reliable and consistent compositions were determined using 1 μm2 area measurements of particles acquired in normal TEM mode where the electron beam was parallel, the degree of specimen damage was at its minimum and good acquisition intensities (>10,000 cps) were acquired. Based on 528 TEM-EDX area analyses, the composition of Wyoming montmorillonites (SWy-1, SWy-2, and SWy-3) was studied in their natural and Ca-saturated states from thin (<50 nm thick) particle aggregates lying on lacey carbon films. Overall, the TEM-EDX results confirmed the heterogeneous charge distributions of montmorillonite at the particle and sample levels. The average composition per formula unit of SWy-1 to -3 was determined as: (Na0.12Ca0.04Mg0.03K0.02)(Si3.91Al0.09)(Al1.57Mg0.27Fe0.19)2.03 O10(OH)2 · nH2O, where the tetrahedral and octahedral layer charges are –0.09 and –0.19 per O10(OH)2, respectively, and the total layer charge ranges from –0.25 to –0.30 per O10(OH)2 (mean of –0.28). This study demonstrates how TEM-EDX can provide new insight into the natural heterogeneities of smectite chemistry as long as adequate calibration and specimen damage control procedures are implemented.
This book takes as its starting point recent debates over the dematerialisation of subject matter which have arisen because of changes in information technology, molecular biology, and related fields that produced a subject matter with no obvious material form or trace. Arguing against the idea that dematerialisation is a uniquely twenty-first century problem, this book looks at three situations where US patent law has already dealt with a dematerialised subject matter: nineteenth century chemical inventions, computer-related inventions in the 1970s, and biological subject matter across the twentieth century. In looking at what we can learn from these historical accounts about how the law responded to a dematerialised subject matter and the role that science and technology played in that process, this book provides a history of patentable subject matter in the United States. This title is available as Open Access on Cambridge Core.
A new chemical mass balance technique has been developed for simultaneous mineralogical quantification and chemical characterization of soil clays. The procedure includes separation of the whole clay (<2 μm fraction) into six particle size fractions (<0.02, <0.06, <0.2, 0.02–0.06, 0.06–0.2, and 0.2–2 μm fractions), chemical analysis of the whole clay and each of the six fractions, and fitting of a nonlinear chemical mass balance model to the chemical analyses. As written, the chemical mass balance model is valid only for samples containing mixtures of quartz, kaolinite, illite, and mixed-layered smectiteillite. Samples containing carbonates and free iron compounds may be analyzed using the technique if these phases are chemically removed prior to particle size fractionation. Accuracy of the new technique was tested using synthetic data and found to depend on the quality of the input data; however, clay phase quantification within three percentage points of known values was readily achieved. Precision of the technique was evaluated by independently preparing and analyzing five samples of the same soil clay. Standard deviations for clay phase percentages (w:w) in the <2 μm fraction were all less than one percent. The new technique yields accurate determinations of chemistry for the smectitic and illitic phases in mixed-layered smectiteillite, and qualitative estimates for the chemistry of 10 Å-illite. The elemental compositions of quartz and kaolinite are assumed a priori and treated as constants within the non-linear chemical mass balance model.
Otay-type waxy bentonites of San Diego County are illite-smectite (I-S) with 85% dioctahedral smectite mixed with dioctahedral illite showing a Reichweite of 0. Primary or secondary waxy bentonite exposures are found in all Eocene and Oligocene formations of southwest San Diego County and western Baja California north of Ensenada. Primary waxy bentonites formed when hot volcanic ash fell into quiet marine or brackish coastal water. The transformation from glass to bentonite occurred within hours or days but consolidation of the bentonite into its waxy consistency took longer. Primary waxy bentonite consists of 95 wt% I-S with the remainder consisting of volcanic glass shards, sanidine fourling twins, hexagonal biotite crystals and amorphous manganese oxides and hydroxides. Secondary waxy bentonite is primary waxy bentonite that was mixed with nonvolcanic detritus either before consolidation or after consolidation and subsequent erosion. The hydrophobic character of primary waxy bentonite allows it to reflect, accurately, the chemistry and petrology of the original volcanic material. Chemical analysis of primary waxy bentonites shows that the original lava was subduction-related and exhibited petrologic variations nearly identical to those of the modern Cascades of the northern Pacific coast of the lower United States. Primary and secondary waxy bentonites as well as smectites derived from the weathering of volcanic ash that fell outside the waxy bentonite-producing environments are the previously unrecognized products of extensive Eocene and Oligocene subduction-related volcanic activity. Baja California exposures of waxy bentonite demonstrate pre-Pliocene subduction tectonics that gave way to rifting tectonics.
The residual kaolin deposits near Lastarria, South-Central Chile, were formed by weathering of subvolcanic quartz porphyry stocks, which intruded the metamorphic basement of the Coastal Cordillera. The clay fractions (<2 µm) consist mainly of poorly-ordered, very fine-grained kaolinite and lath-shaped illite (17–38 wt. %) with minor amounts of quartz, sanidine, and goethite. A sample from the top of the deposit contains major quantities of gibbsite morphologically indistinguishable from kaolinite flakes. The gibbsite-free clays contain 35.5–36.6 wt. % Al2O3, 0.4–2.6 wt. % Fe2O3, 1.3–3.9 wt. % K2O, and have low TiO2 concentrations (<0.02 wt. %). The absence of quartz veining, the abundance of melt inclusions, and the scarcity of secondary fluid inclusions in quartz phenocrysts from altered rocks imply a lack of significant hydrothermal activity in the quartz porphyries. The δ 18O and δD values of the kaolins indicate formation in a weathering environment at significantly higher annual mean air temperatures (∼12°C) than present mean temperatures of ∼9.4°C. Uplift of the region alone probably cannot account for the change in climate. The stable isotope composition of gibbsite is consistent with an origin of desilication of kaolinite at superficial temperatures. Various criteria proposed to distinguish supergene from hypogene kaolins are discussed.
This chapter considers the uses of sublime blockage for science. The sublime was, on the one hand, a prod for precision and, on the other hand, a nod to skepticism and mystery, potentially ennobling an otherwise mechanical science. The chapter shows how astronomers, biologists, chemists, electricians, and natural historians and neurologists exploited sublime blockage either to elevate science above crude mechanism or butchery or to engage in skepticism so that it could arguably further scientific research. Such engagement with blockage paved the way for Franz Anton Mesmer’s quackery along with Benjamin Franklin’s efforts to defeat it, but quackery proved to be a more robust foe than anticipated.
A new lichen species, Lecanora zeorina Li J. Li & Printzen is described here from the south-west of China. Lecanora zeorina is characterized by its somewhat areolate-squamulose thallus, zeorine to lecanorine apothecia, an epihymenium without crystals around expanded paraphyses tips, an amphithecium with large calcium oxalate crystals and the production of atranorin. A new combination, Lecanora crystalliniformis (B.G. Lee & Hur) Li J. Li & Printzen, is based on Protoparmeliopsis crystalliniformis B.G. Lee & Hur, which was described as a new species from South Korea. Collections from China are almost identical in morphology and chemistry, and are phylogenetically closely related. Phylogenetic reconstructions based on ITS and mtSSU suggest that these two lecanoroid species belong in Lecanora s. str. where they form a sister group to sorediate species such as L. barkmaniana Aptroot & Herk and L. variolascens Nyl. Detailed descriptions, discussions, distributions and phylogenetic trees, based on multiple collections, are presented.
Teresa Connolly argues that a profound understanding of key chemistry concepts and processes is as fundamental to scientific literacy as mastering complex procedures and skills, such as performing experiments, interpreting data or communicating one’s findings using specific text types. However, she points out that such an understanding of chemical concepts is inhibited not only by learners’ poor command of academic language but also by the fact that chemical processes can be observed at different levels of abstraction. This poses a specific challenge in chemistry because learners often report having difficulties distinguishing clearly between processes at the sub-microscopic, the microscopic and the macroscopic level, which will lead to misconceptions and prevent deeper understanding. To address that issue, Connolly’s deeper learning episode on redox reactions offers engaging ways of promoting scientific reasoning through a series of student-led experiments and inquiry. Systematic guidance in academic language use will enable learners to express their findings and observations precisely and adequately and thus help them distinguish the processes occurring at various levels of abstraction with increasing ease and confidence.
This new collection enables students and general readers to appreciate Coleridge’s renewed relevance 250 years after his birth. An indispensable guide to his writing for twenty-first-century readers, it contains new perspectives that reframe his work in relation to slavery, race, war, post-traumatic stress disorder and ecological crisis. Through detailed engagement with Coleridge’s pioneering poetry, the reader is invited to explore fundamental questions on themes ranging from nature and trauma to gender and sexuality. Essays by leading Coleridge scholars analyse and render accessible his extraordinarily innovative thinking about dreams, psychoanalysis, genius and symbolism. Coleridge is often a direct and gripping writer, yet he is also elusive and diverse. This Companion’s great achievement is to offer a one-volume entry point into his incomparably rich and varied world.
This chapter considers the characteristics and contexts of three eighteenth-century encyclopaedic dictionaries: Cyclopaedia (1728) by Ephraim Chambers, A medicinal dictionary (1742–45) by Robert James, and The first part of a dictionary of chemistry (1789) by James Keir, especially in relation to their own comments on their intentions. Chambers’s is generalist, while the other two are specialist works on medicine and chemistry. The Cyclopaedia had a long and acclaimed afterlife, while James’s dictionary was translated into French and Italian, but did not reach a second edition in England. Keir’s remained unfinished. An attempt is made to position these works in their larger lexicographical and scientific context, primarily through their paratexts.
Species are fundamental units used to describe and interpret nature. Molecular delimitation methods have shown that many species cannot be diagnosed using morphological traits. We suggest that cryptic species represent an opportunity to progress Linnean taxonomy,. We examine what can be learned from sympatric cryptic species pairs that occupy the same habitat. Their sympatry is possible under two conditions, 1) reproductive isolation, 2) the effects of interspecific competition on population growth must be neutralised. Understanding the mechanisms that maintain species differences and integrating this understanding into taxonomy will help to delineate species boundaries. We first examine the mechanisms of cryptic species origin. Then we review some well-documented cases of reproductive isolation between cryptic species, focusing on prezygotic isolation mechanisms mediated by premating recognition and communication. We follow with examples of co-occurring cryptic species, focusing on mechanisms of coexistence and ecological niche differentiation. Both mate recognition and niche differentiation are grounded in the sensory worlds that animals experience. Sensory ecology provides tools to explore hitherto hidden diversity and so identify, misunderstood and unprotected in this time of rapid anthropogenic global change. We argue that the field of sensory ecology has a potential for improving taxonomy
This study investigated the molecular, chemical and morphological variation in the Usnea pectinata aggregate using 42 specimens, 22 from Tanzania and 20 from São Tomé and Príncipe. A total of 31 sequences (13 ITS, 13 nuLSU and 5 RPB1) were generated. The results are presented in two phylogenies: first a three-markers ‘backbone’ phylogeny for the U. pectinata aggregate, where six distinct, strongly supported subclades indicate considerable genetic variation in the dataset; and second, an ITS phylogeny with 47 terminals along with a mapping of morphological and chemistry data. Several well-supported monophyletic clades were recovered in both phylogenies and these may well represent separate species in the complex referred to here as the U. pectinata aggregate. Three morphotypes characterized by axis pigmentation and four by branch shape were noted. Six chemotypes were observed.
The immunohistochemistry assay has evolved over many years. Primarily based on an antibody binding to epitopes in tissue sections, the technology has come a long way from its earliest manifestation using direct fluorescence labels. Current polymer technology is the result of many variations and adaptations on technique throughout the years. Indeed, much of its continued development is owed to early pioneers who experimented and overcame technical boundaries. This chapter is a broad discussion about what immunohistochemistry is from the historical perspective, and the individuals who have contributed to its expansion. It includes a journey about protocol adaptations and explanations of their context and applications. This chapter provides a sound basis in which to explore the rest of the book.
In France, a consolidated research ecosystem, including different national structures, has been developed to promote excellence in academic research. While research-oriented curricula are well organized at doctoral and master levels, the national policy perspective has not yet considered introducing academic research at undergraduate level. However, various initiatives exist within the institutions to encourage the participation of undergraduate students in research activities. In this chapter, we introduce some initiatives developed towards undergraduate research in the context of the French national system of education.
Chemical structure is a vital consideration early in the drug development process. Its role in analysis of safety and efficacy is relatively diminished after drugs are approved for clinical use. This interdisciplinary study explores a strategy by which readily available clinical data may be used along with structural features of drugs to identify associations with potential utility for both clinical decision-making and drug development.
Methods:
Chemical functional groups and structural groups (SGs) of 261 drugs were manually classified in tiers, and their incidence of gastrointestinal (GI) and central nervous system (CNS) adverse drug reactions (ADRs) were obtained from a clinical database. Drugs with an GI or CNS ADR incidence of at least 10% were analyzed for correlations with their functional and SGs.
Results:
Eight statistically significant associations were detected by preliminary analysis: piperazine and methylene groups were associated with higher rate of CNS ADRs; while amides, secondary alcohols, and di-substituted phenyl groups were associated with lower rates of GI or CNS ADRs or both.
Conclusions:
Although further study is necessary to understand these associations and build upon this strategy, this exploratory analysis establishes a methodology by which chemical properties of drugs may be used to aid in clinical decision-making when choosing between otherwise equivalent drug therapy options, as the presence of specific groups on drugs may be associated with increased or decreased risks of specific ADRs.
Chapter 6 chronicles how money as social technology was reconfigured during the eighteenth and nineteenth centuries. It examines economic and philanthropic discourse as well as government practice between 1750 and 1850 to explain the motives for a quick succession of currency reforms in the nineteenth century, that profoundly transformed the material properties of public money in circulation. Cheap but precise mass production was especially important in order to issue low-denomination coins, used primarily for wage payments and retail, that would be fully conversant with the official monetary standard. In order to explain why the Dutch came to take a more hostile stance towards multiple currencies circulating in their territory, the chapter delineates how a 'national economy', forged through monetary exchange, became first an ideological and then a bureaucratic reality. While national currency did not do away with plurality of money in use, especially in the Dutch–Prussian borderland that is the main locale of this book, the strong discourse of technological superiority of uniform, centrally managed currency made it more difficult to think about plurality as something other than chaos.
Chapter 4 explores how artisanal knowledge helped sustain early modern monetary order by making and unmaking the intrinsic value of precious metal. Intrinsic value was a conceptual tool and a material practice that allowed people to collapse many coins into one another and to forge units from multiples. Effectively, this meant establishing a network of corresponding values between specific batches of coins. The papers of a family of assayers from The Hague offer a fine-grained picture of the processes involved. Small differences in the precious metal content of coins aroused creeping suspicion, anger, and even physical violence because it was believed that the metal of a coin reflected the mettle of a person. This was particularly true for the masters of the mint, whose reputation was tied to the reputation of their coins. Making coins, and making them work, involved financial and legal expertise, but the artisanal knowledge of assayers and other metal-workers was key. Their practices such as sampling, using high-precision balances and powerful acids, note-taking, the rule of three, and algebraic calculation allowed people to hold on to the convention that metals had an intrinsic, quantifiable value in spite of fluctuations in the price of silver and gold, both across time and across the globe.
Thomas Kuhn's The Structure of Scientific Revolutions offers an insightful and engaging theory of science that speaks to scholars across many disciplines. Though initially widely misunderstood, it had a profound impact on the way intellectuals and educated laypeople thought about science. K. Brad Wray traces the influences on Kuhn as he wrote Structure, including his 'Aristotle epiphany', his interactions, and his studies of the history of chemistry. Wray then considers the impact of Structure on the social sciences, on the history of science, and on the philosophy of science, where the problem of theory change has set the terms of contemporary realism/anti-realism debates. He examines Kuhn's frustrations with the Strong Programme sociologists' appropriations of his views, and debunks several popular claims about what influenced Kuhn as he wrote Structure. His book is a rich and comprehensive assessment of one of the most influential works in the modern sciences.