In this paper, the design of a circularly polarized (CP) multiple-input–multiple-output (MIMO) antenna system is presented, utilizing a dielectric resonator (DR). This presented antenna system is subsequently integrated with a multifunctional filter, all meticulously structured on a single substrate. The multifunctional filter operates in three modes: reconfigurable band-pass and band-reject filter as well as all-pass filter. The overall structure works as a tunable filtenna. The designed filtenna is expanded into a two-port MIMO system on a unified substrate, providing strong port isolation below −28.5 dB. The overall dimension of proposed radiator is 180 × 180 × 1.6 mm3. The value of peak gain is 5.19 dBic. By switching the states of PIN diodes, the designed filtenna operates as a sensing and communicating antenna for interweave and underlay cognitive radios (CRs). The proposed antenna supports the CP waves within the working band, i.e., 3.6–4.5 GHz. The simulated results are validated by comparing them with the measured results showing less variation among them. MIMO parameters, including the envelope correlation coefficient and diversity gain, have been calculated for the proposed filtenna, representing its suitability for 5G-CR applications.