Cell and gene therapies derive from a substantial manipulation of cells or the application of gene editing techniques. They are promising products because they enable therapy personalisation, are potentially helpful for treating rare or resistant diseases, and may become useful in future epidemics. Because of this strategic worth, the infrastructure needed for manufacturing these therapies is turning into a subdomain within the domain of critical infrastructures (CIs), understood as the structures whose operation is key for the integrity and security of a nation. This paper analyses why cell and gene therapy infrastructure can be considered as an emergent CI domain, stressing three aspects: automated manufacturing equipment; software solutions (including the growing adoption of artificial intelligence and cloud technology); and human expertise. These complex manufacturing systems, which are becoming increasingly automated and digitalised, may be surrounded by new risks and vulnerability points, which requires adequate regulatory solutions and governance initiatives. A comprehensive approach is therefore advanced here, where therapy manufacture has medical and technological relevance, but is equally crucial from the viewpoint of nations’ public health and internal stability.

The Black Sea is a substantial inland sea and has a very fascinating border on the east and west. It reaches into the Mediterranean through the straits, into Europe via rivers, and toward Asia via the Caucasus. The human relations developed through this network has led to the emergence of cultural landscape elements in the region. The natural landscape elements that have developed inherently in the natural beauty of the region have also become one of the most important pieces of heritage in the region. In this region, many uncontrolled practices that have taken place in recent years have rapidly degraded the cultural and natural landscape. The purpose of this study is to emphasize the beauty of nature, which makes the Eastern Black Sea region one of the most significant cultural and natural heritage areas of the world, and to explore its impact on human life in the context of water heritage as well as to address the dynamic risks of losing this beauty. In this study, the recognition of water as a heritage component is conceptually discussed in the context of the inherent cultural heritage and natural heritage. The unifying and integrative power of the multicultural water heritage that the region possesses is explicated.

Cuba faces a dilemma between continuing its current portfolio of biotechnology drugs and vaccines with lower profitability or renewing its product portfolio with the associated costs and risks.

French whistleblower legislation establishes a unified legal regime for the treatment of reports and for the protection of whistleblowers. Drawing on French whistleblower law, recently amended by the transposition of Directive 2019/1937 of 23 October 2019, this article examines whether the specific features of whistleblowing in relation to public health and environmental risks are adequately addressed by this unified regime. The article identifies four key factors for the effective handling of whistleblowing relating to public health and the environment: (1) the possibility of protecting whistleblowers who report facts gathered outside the workplace; (2) the possibility of protecting legal persons as whistleblowers; (3) the possibility of carrying out in-depth investigations to characterise the reality of the risks reported; and (4) the possibility of archiving whistleblowing in order to detect weak signals of risks over the long term. In these four areas, the article provides a nuanced diagnosis of the situation in French law and offers suggestions for improvement.

Child development is strongly influenced by maternal characteristics. Maternal sensitivity, as well as risks to and outcomes of sensitive maternal style, are well studied in industrialised western contexts, but it is unclear if this is the case for other contexts. Sub-Saharan Africa has been subjected to and continues to negotiate socio-economic and psychological sequelae of colonial and race-based politics: exploring the nature and outcomes of early caregiver input in such challenging conditions is imperative. This scoping review thus aims to 1) evaluate the nature and extent of quantified observational assessments of dyadic interactions, with a focus on maternal sensitivity, in Sub-Saharan Africa and 2) ascertain which risk and outcome factors have been examined in relation to maternal sensitivity. Study quality and cross-cultural appropriateness will also be considered. The search using expanded search terms yielded 20 papers –four characterizing maternal sensitivity or style, eight examining maternal sensitivity in relation to risks and outcomes, and eight intervention studies examining efforts to improve maternal sensitivity. Most research was conducted in South Africa – only seven studies were conducted in four other countries. Researchers used a wide array of coding schemes, mostly developed in the west. Ten studies made some adaptations to measures. Language issues and cultural considerations were often not explicitly addressed. Taken together, very limited research on this important topic exists. For the work that does exist, questions around westernized assumptions, language, and appropriateness of measures remain. Substantially more research, informed by both culturally flexible conceptualizations and methodological rigour, is required.

Some decision situations are so objectionable or repugnant that people refuse to make a choice. This paper seeks to better understand taboo responses, and to distinguish choices that are truly taboo from those that are merely difficult or confusing. Using 22 scenarios that describe potentially taboo issues, Experiment 1 explores reasons for disapproval of the scenarios. We measure a large number of possible reasons for disapproval and a variety of preference responses (including willingness to accept), in order to test for subtleties in taboo responses. We also test cognitive and affective responses to the scenarios. Experiment 2 further explores the interaction, found in Experiment 1, between affective and cognitive factors. Taken as a whole, our results show that people are able to indicate their disapproval consistently across a variety of preference elicitation methods, that their disapproval is better understood as an attitude measure than as an economic valuation (even when the measure is in monetary terms), and that taboo responses are driven primarily by affect.