Field experiments were conducted to evaluate postemergence (POST)-applied tank mixtures of 560, 1,120, and 1,680 g ai/ha glyphosate with or without 1,120 g ai/ha SAN 582 (proposed name, dimethenamid) as burndown treatments or POST in glyphosate-tolerant soybean. SAN 582 was not antagonistic with glyphosate at the glyphosate rates evaluated. In the burndown study, glyphosate controlled horseweed 98% or more and curly dock 82% or more with or without SAN 582. However, broadleaf signalgrass emerged after the burndown treatments were applied. All tank mixtures that included SAN 582 controlled broadleaf signalgrass 84 to 96%, 6 wk after treatment. In the glyphosate-tolerant soybean study, glyphosate controlled barnyardgrass and johnsongrass present at the time of application 89% or more, regardless of rate. Tank mixtures of SAN 582 with glyphosate controlled late-season flushes of barnyardgrass through residual activity of the SAN 582. Applying SAN 582 with glyphosate improved soybean yield 500 kg/ha over glyphosate applied alone.