Field trials were conducted in New Jersey during 1991 and 1992 to evaluate the efficacy of nicosulfuron, primisulfuron, dicamba, and clopyralid on horsenettle control in field corn. Horsenettle biomass was reduced 74%, 68%, 64%, 61%, 48%, and 40% by primisulfuron + dicamba, primisulfuron, nicosulfuron + dicamba, dicamba, clopyralid, and nicosulfuron, respectively. No treatment was statistically more effective than dicamba. Corn yields were not influenced by the herbicide treatments. Horsenettle populations were not reduced by any treatment.