The impact of basal ganglia dysfunction on semantic processing was
investigated by comparing the performance of individuals with
nonthalamic subcortical (NS) vascular lesions, Parkinson's disease
(PD), cortical lesions, and matched controls on a semantic priming
task. Unequibiased lexical ambiguity primes were used in auditory
prime-target pairs comprising 4 critical conditions; dominant related
(e.g., bank–money), subordinate related (e.g.,
bank–river), dominant unrelated (e.g.,
foot–money) and subordinate unrelated (e.g.,
bat–river). Participants made speeded lexical decisions
(word/nonword) on targets using a go–no-go response. When a
short prime–target interstimulus interval (ISI) of 200 ms was
employed, all groups demonstrated priming for dominant and subordinate
conditions, indicating nonselective meaning facilitation and intact
automatic lexical processing. Differences emerged at the long ISI (1250
ms), where control and cortical lesion participants evidenced selective
facilitation of the dominant meaning, whereas NS and PD groups
demonstrated a protracted period of nonselective meaning facilitation.
This finding suggests a circumscribed deficit in the selective
attentional engagement of the semantic network on the basis of meaning
frequency, possibly implicating a disturbance of
frontal–subcortical systems influencing inhibitory semantic
mechanisms. (JINS, 2003, 9, 1041–1052.)