Currently, electroretinograms (ERGs) are mainly recorded while using flashes as stimuli. In this review, we will argue that strong flashes are not ideal for studying visual information processing. ERG responses to periodic stimuli may be more strongly associated with the activity of post-receptoral neurons (belonging to different retino-geniculate pathways) and, therefore, be more relevant for visual perception. We will also argue that the use of periodic stimuli may be an attractive addition to clinically available retinal electrophysiological methods.

Many areas of research require measuring psychometric functions or their descriptors (thresholds, slopes, etc.). Data for this purpose are collected with psychophysical methods of various types and justification for the interpretation of results arises from a model of performance grounded in signal detection theory. Decades of research have shown that psychophysical data display features that are incompatible with such framework, questioning the validity of interpretations obtained under it and revealing that psychophysical performance is more complex than this framework entertains. This paper describes the assumptions and formulation of the conventional framework for the two major classes of psychophysical methods (single- and dual-presentation methods) and presents various lines of empirical evidence that the framework is inconsistent with. An alternative framework is then described and shown to account for all the characteristics that the conventional framework regards as anomalies. This alternative process model explicitly separates the sensory, decisional, and response components of performance and represents them via parameters whose estimation characterizes the corresponding processes. Retrospective and prospective evidence of the validity of the alternative framework is also presented. A formal analysis also reveals that some psychophysical methods and response formats are unsuitable for separation of the three components of observed performance. Recommendations are thus given regarding practices that should be avoided and those that should be followed to ensure interpretability of the psychometric function, or descriptors (detection threshold, difference limen, point of subjective equality, etc.) obtained with shortcut methods that do not require estimation of psychometric functions.

Previous studies have shown that multiple sclerosis (MS) affects the visual system, mainly by reducing contrast sensitivity (CS), a function that can be assessed by measuring contrast sensitivity function (CSF). To this end, we measured both the CSF for sine-wave gratings and angular frequency stimuli with 20 participants aged between 21 and 44 years, of both genders, with normal or corrected to normal visual acuity. Of these 20 participants, there were 10 volunteers with clinically defined MS of the relapsing–remitting clinical form, with no history of optic neuritis (ON), as well as 10 healthy volunteers who served as the control group (CG). We used a forced-choice detection paradigm. The results showed reduced CS to both classes of stimuli. Differences were found for sine-wave gratings at spatial frequencies of 0.5, 1.25, and 2.5 cycles per degree (cpd) (P < 0.002) and for angular frequency stimuli of 4, 24, and 48 cycles/360° (P < 0.05). On the one hand, comparing the maxima of the respective CSFs, the CS to angular frequency stimuli (24 cycles/360°) was 1.61-fold higher than that of the CS to vertical sine-wave gratings (4.0 cpd) in the CG; for the MS group, these values were 1.55-fold higher. On the other hand, CS in the MS group attained only 75% for 24 cycles/360° and 78% for 4.0 cpd of the 100% CS estimates found for the CG at the peak frequencies. These findings suggest that MS affects the visual system, mostly at its maximum contrast sensitivities. Also, since angular frequencies and sine-wave gratings operate at distinct levels of contrast in the visual system, MS seems to affect CS at both high and low levels of contrast.

Human experience of temporal durations exhibits a multi-regional structure, with more or less distinct boundaries, or horizons, on the scale of physical duration. The inner horizons are imposed by perceptual thresholds for simultaneity (≈ 3 ms) and temporal order (≈ 30 ms), and are determined by the dynamical properties of the neural substrate integrating sensory information. Related to the inner horizon of experienced time are perceptual or cognitive “moments.” Comparative data on autokinetic times suggest that these moments may be relatively invariant (≈ 102 ms) across a wide range of species. Extension of the “sensible present” (≈ 3 s) defines an intermediate horizon, beyond which the generic experience of duration develops. The domain of immediate duration experience is delimited by the ultimate outer horizon at about ≈102 s, as evidenced by analysis of duration reproduction experiments (reproducibility horizon), probably determined by relaxation times of “neural accumulators.” Beyond these phenomenal horizons, time is merely cognitively (re)constructed, not actually experienced or “perceived,” a fact that is frequently ignored by contemporary time perception research. The nyocentric organization of time experience shows an interesting analogy with the egocentric organization of space, suggesting that structures of subjective space and time are derived from active motion as a common experiential basis.

The main purpose of the present study was to investigate whether in natural environment, using very large physical distances, there is a trend to overconstancy for distance estimates during development. One hundred and twenty-nine children aged 5 to 13 years old and twenty-one adults (in a control group), participated as observers. The observer's task was to bisect egocentric distances, ranging from 1.0 to 296.0 m, presented in a large open field. The analyses focused on two parameters, constant errors and variable errors, such as measuring accuracy and precision, respectively. A third analysis focused on the developmental pattern of shifts in constancy as a function of age and range of distances. Constant error analysis showed that there are two relevant parameters for accuracy, age, and range of distances. For short distances, there are three developmental stages: 5-7 years, when children have unstable responses, 7-11, underconstancy, and 13 to adulthood, when accuracy is reached. For large distances, there is a two-stage development: 5-11 years, with severe underconstancy, and beyond this age, with mild underconstancy. Variable errors analyses indicate that precision is noted for 7 year-old children, independently of the range of distances. The constancy analyses indicated that there is a shift from constancy (or slightly overconstancy) to underconstancy as a function of physical distance for all age groups. The age difference is noted in the magnitude of underconstancy that occurs in larger distances, where adults presented lower levels of underconstancy than children. The present data were interpreted as due to a developmental change in cognitive processing rather than to changes in visual space perception.

Class A psychophysical observations are based on the linking hypothesis that perceptually distinguishable stimuli must correspond to different brain events. Class B observations are related to the appearance of stimuli not their discriminability. There is no clear linking hypothesis underlying Class B observations, but they are necessary for studying the effects of context on appearance, including a large class of phenomena known as “illusions.” Class B observations are necessarily measures of observer bias (Fechner’s “constant error”) as opposed to Class A measures of sensitivity (Fechner’s “variable error”). It is therefore important that Class B observations distinguish between response biases, decisional biases, and perceptual biases. This review argues that the commonly used method of single stimuli fails to do this, and that multiple-alternative forced choice (mAFC) methods can do a better job, particularly if combined with a roving pedestal.

It is a matter of debate whether X-linked dichromacy is accompanied by enhanced achromatic processing. In the present study, we used sinusoidally modulated achromatic gratings under photopic conditions to compare the contrast sensitivity (CS) of protanopes, deuteranopes, and normal trichromats. 36 male volunteers were examined. CS was tested in static and dynamic conditions at nine different spatial frequencies. The results support the assumption that X-linked color-defective observers are at an advantage in terms of achromatic processing. Both protanopes and deuteranopes had significantly better CS than controls in both the static and the dynamic conditions. In the static condition, the advantage was observed especially at higher spatial frequencies, whereas in the dynamic condition, it was seen also at lower frequencies. The results are interpreted in terms of decreased chromatic modulation of the luminance channel and the early plasticity of the parvocellular system.

Over the last 35 years or so, there has been substantial progress in revealing and characterizing the many interesting and sometimes mysterious sensory abnormalities that accompany amblyopia. A goal of many of the studies has been to try to make the link between the sensory losses and the underlying neural losses, resulting in several hypotheses about the site, nature, and cause of amblyopia. This article reviews some of these hypotheses, and the assumptions that link the sensory losses to specific physiological alterations in the brain. Despite intensive study, it turns out to be quite difficult to make a simple linking hypothesis, at least at the level of single neurons, and the locus of the sensory loss remains elusive. It is now clear that the simplest notion—that reduced contrast sensitivity of neurons in cortical area V1 explains the reduction in contrast sensitivity—is too simplistic. Considerations of noise, noise correlations, pooling, and the weighting of information also play a critically important role in making perceptual decisions, and our current models of amblyopia do not adequately take these into account. Indeed, although the reduction of contrast sensitivity is generally considered to reflect “early” neural changes, it seems plausible that it reflects changes at many stages of visual processing.

Simulation studies have shown how Bayesian adaptive estimation methods should be set up for optimal performance. We assessed the extent to which these results hold up for human observers, who are more subject to failure than simulation subjects. Discrimination and detection experiments with two-alternative forced-choice (2AFC) tasks were used for that purpose. Forty estimates of the point of subjective equality (PSE, or the 50% correct point on the psychometric function for discrimination) and 32 estimates of detection threshold (the 80% correct point on the psychometric function for detection) were taken for each of four observers with the optimal Bayesian method, while data for fitting the psychometric function Ψ were gathered concurrently with an adaptive method of constant stimuli governed by fixed-step-size staircases. The estimated parameters of the psychometric function served as a criterion for comparison. In the discrimination task, PSEs for each observer were distributed around the independently estimated 50% correct point on Ψ and their variability was occasionally minimally larger than simulation results indicated it should be. In the detection task, the distribution of threshold estimates was consistently above the independently estimated 80% correct point on Ψ and their variability was as expected from simulations. A close analysis of these results suggests that the optimal Bayesian method is affected by growing inattention or fatigue in detection tasks (factors that are not considered in simulations), and limits the practical applicability of Bayesian estimation of detection thresholds.

Difficulty with selective attention is a frequent complaint of adult patients with ADHD, but selective attention tasks have not provided robust evidence of attentional dysfunction in this group. Two experiments examine this puzzle by distinguishing between failures of spatial selection and problems due to sensitivity to perceptual interference. In Experiment 1, we measured the level of perceptual interference generated by targets in crowded displays with nearby distractors by comparing luminance thresholds in both distractor-present (noise) and distractor-absent (clean) displays. ADHD and control participants had comparable thresholds for clean displays, but ADHD individuals had elevated thresholds to crowded displays. These effects could be explained in two distinct ways. Deficits may have arisen from amplified visual interference in the noise condition, or from abnormalities in top-down attentional processes that reduce visual interference. Experiment 2 adjusted for individual perceptual differences with clean and noise displays, before measuring visual interference resolution at attended versus unattended locations. ADHD and control groups had comparable interference resolution at attended locations. These results suggest that perceptual interference rather than spatial attention deficits may account for some deficits in ADHD. This putative deficit in sensory function highlights a potential early-stage perceptual processing deficit in ADHD distinct from selective attention. (JINS, 2012, 18, 511–520)

Visual masking can result from the interference of perceptual signals. According to the principle of functional specialization, interference should be greatest when signal and mask belong to the same visual attribute (e.g., color or motion) and least when they belong to different ones. We provide evidence to support this view and show that the time course of masking is visual attribute specific. First, we show that a color target is masked most effectively by color (homogeneous target-mask pair) and least effectively by motion (heterogeneous pair) and vice versa for a motion target. Second, we show that the time at which the mask is most effective depends strongly on the target-mask pairing. Heterogeneous masking is strongest when the mask is presented before the target (forward masking) but this is not true of homogeneous masking. This finding supports a delayed cross-feature interaction due to segregated processing sites. Third, lengthening the stimulus onset asynchrony between target and mask leads to a faster improvement in color than in motion detectability, lending support for a faster color processing system and consistent with reports of perceptual asynchrony in vision. In summary, we present three lines of psychophysical evidence, all of which support a segregated neural coding scheme for color and motion in the human brain.