Objective - To discuss, after a description of the main models of classification of affective disorders, the main features of the ICD-10 classification of these disorders, the main differences between ICD-10 and ICD-9 and a comparison with DSM-III-R classification. Results - The analysis of the classification of these disorders as reported in ICD-10 shows that their nosographic sistematization is a complex task. In any case ICD-10 represents a significant improvement compared to ICD-9 and has included many of the guidelines of DSM-III-R. Conclusions - ICD-10 proposes a syntesis between different schools and traditions taking into account the results emerged by research in this field over the last twenty years.