Behavioral Genetics of the Mouse

doi:10.1017/CBO9781107360556

The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders: from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

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Contents

Behavioral Genetics of the Mouse Volume II - Half title page
pp i-i
Genetic Mouse Models of Neurobehavioral Disorders
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Series page
pp ii-ii
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Behavioral Genetics of the Mouse Volume II - Title page
pp iii-iii
Genetic Mouse Models of Neurobehavioral Disorders
- By Susanna Pietropaolo, Frans Sluyter, Wim E. Crusio
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Copyright page
pp iv-iv
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Dedication
pp v-vi
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Contents
pp vii-viii
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Contributors
pp ix-xii
- By Sofya Abazyan, Saskia S. Arndt, Jonathon C. Arnold, Sandra Beeské, Odd-Geir Berge, Valerie J. Bolivar, David Borchelt, Marie-Françoise Chesselet, Yoon H. Cho, Angelo Contarino, John C. Crabbe, Wim E. Crusio, Bianca De Filippis, Mara Dierssen, Stephanie C. Dulawa, Emily C. Eastwood, Haim Einat, Raul R. Gainetdinov, David Gordon, Guy Griebel, F. Scott Hall, John H. Harkness, Christopher Janus, Zhengping Jia, Nirit Kara, Tim Karl, Martien J. H. Kas, Federica Klaus, Robert Lalonde, Glenda Lassi, Giovanni Laviola, Iddo Magen, Stephen C. Maxson, Douglas Ashley Monks, Rebecca E. Nordquist, Lucy R. Osborne, Tamara J. Phillips, Alisdair R. Philp, Marina R. Picciotto, Susanna Pietropaolo, Mikhail V. Pletnikov, Christopher R. Pryce, James L. Resnick, Laura Ricceri, Frans Sluyter, Emily Y. Smith, Ichiro Sora, Tatyana D. Sotnikova, Rebecca C. Steiner, Ortrud K. Steinlein, Catherine Strazielle, Enejda Subashi, Ashlyn Swift-Gallant, Aki Takahashi, Kevin Talbot, Stewart Thompson, Valter Tucci, F. Josef van der Staay, Gertjan van Dijk, Nancy S. Woehrle
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Section 1 - Introduction to genetic mouse models of neurobehavioral disorders
pp 1-17
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1 - Introduction
pp 1-3
Genetic mouse models of neuropsychiatric disorders
- By Frans Sluyter, Susanna Pietropaolo, Wim E. Crusio
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2 - Developing mouse models of neurobehavioral disorders
pp 4-17
When is a model a good model?
- By F. Josef van der Staay, Saskia S. Arndt, Rebecca E. Nordquist
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Section 2 - Perception disorders
pp 18-34
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3 - Pain disorders
pp 18-25
- By Odd-Geir Berge
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4 - Disorders of the visual system
pp 26-34
- By Stewart Thompson, Alisdair R. Philp
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Section 3 - Autonomous and motor disorders
pp 35-85
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5 - Obesity and anorexia
pp 35-45
- By Gertjan van Dijk, Martien J. H. Kas
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6 - Sleep disorders
pp 46-55
- By Glenda Lassi, Valter Tucci
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7 - Cerebellardisorders
pp 56-62
- By Robert Lalonde, Catherine Strazielle
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8 - Motor disorders
pp 63-78
- By David Gordon, Kevin Talbot
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9 - Epilepsy
pp 79-85
- By Ortrud K. Steinlein
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Section 4 - Social dysfunction and mental retardation
pp 86-239
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10 - Pathological aggression
pp 86-96
- By Frans Sluyter, Aki Takahashi, Stephen C. Maxson
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11 - Disorders of sex
pp 97-112
- By Ashlyn Swift-Gallant, Douglas Ashley Monks
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12 - Autism
pp 113-133
- By Valerie J. Bolivar
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13 - Rett syndrome
pp 134-145
- By Laura Ricceri, Bianca De Filippis, Giovanni Laviola
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14 - Fragile X syndrome
pp 146-163
- By Susanna Pietropaolo, Enejda Subashi
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15 - Attention-deficit hyperactivity disorder
pp 164-172
- By Tatyana D. Sotnikova, Raul R. Gainetdinov
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16 - Obsessive–compulsive disorder and Gilles de la Tourette syndrome
pp 173-188
- By Nancy S. Woehrle, Stephanie C. Dulawa
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17 - Schizophrenia
pp 189-207
- By Sofya Abazyan, Mikhail V. Pletnikov
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18 - Down syndrome
pp 208-219
- By Mara Dierssen
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19 - Prader–Willi and Angelman syndromes
pp 220-231
- By Emily Y. Smith, James L. Resnick
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