Skip to main content Accessibility help
×
Hostname: page-component-5b777bbd6c-2c8nx Total loading time: 0 Render date: 2025-06-18T20:25:17.812Z Has data issue: false hasContentIssue false

Management of Moderate or Severe Traumatic Brain Injury

Published online by Cambridge University Press:  29 May 2025

Saeed Kayhanian
Affiliation:
University of Cambridge
Erta Beqiri
Affiliation:
University of Cambridge
Ari Ercole
Affiliation:
University of Cambridge
Adel Helmy
Affiliation:
University of Cambridge

Summary

The management of patients with moderate and severe traumatic brain injury (TBI) is centred on the intensive care management to limit the extent of secondary injury to the brain, following the primary trauma. This management aims to optimise the homeostatic environment of the brain after injury and can be guided by multi-modality monitoring, including intracranial pressure (ICP) monitoring. This management often follows a tiered approach to introducing more aggressive interventions to correct physiology, based on evidence for ongoing secondary injury, such as raised ICP. The balance between risk and benefit for these interventions for individual patients is difficult, particularly in the absence of high quality randomised trials for many interventions in this area. In this Element, the authors outline both the approach to intensive care management of moderate and severe TBI, as well as the evidence base available for the interventions discussed.
Get access
Type
Element
Information
Online ISBN: 9781009437677
Publisher: Cambridge University Press
Print publication: 12 June 2025

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Element purchase

Temporarily unavailable

References

Carney, N, Totten, AM, Ullman, JS, et al. Guidelines for the Management of Severe Traumatic Brain Injury 4th ed. 2016.Google Scholar
Hawryluk, GWJ, Aguilera, S, Buki, A, et al. A Management Algorithm for Patients with Intracranial Pressure Monitoring: The Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC). Intensive Care Med. 2019;45:1783–94. https://doi.org/10.1007/S00134-019-05805-9.CrossRefGoogle ScholarPubMed
Singer, M, Young, PJ, Laffey, JG, et al. Dangers of Hyperoxia. Crit. Care 2021;25:115. https://doi.org/10.1186/S13054-021-03815-Y.CrossRefGoogle ScholarPubMed
De Franca, SA, Tavares, WM, Salinet, ASM, Paiva, WS, Teixeira, MJ. Early Tracheostomy in Severe Traumatic Brain Injury Patients: A Meta-Analysis and Comparison with Late Tracheostomy. Crit. Care Med. 2020;48:E325–31. https://doi.org/10.1097/CCM.0000000000004239.CrossRefGoogle ScholarPubMed
Li, M, Chen, T, Chen, S Da, Cai, J, Hu, YH. Comparison of Equimolar Doses of Mannitol and Hypertonic Saline for the Treatment of Elevated Intracranial Pressure after Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Medicine 2015;94:e668. https://doi.org/10.1097/MD.0000000000000668.CrossRefGoogle Scholar
Andrews, PJD, Sinclair, HL, Rodríguez, A, et al. Therapeutic Hypothermia to Reduce Intracranial Pressure after Traumatic Brain Injury: the Eurotherm3235 RCT. Health Technol Assess (Rockv) 2018;22:1133. https://doi.org/10.3310/HTA22450.CrossRefGoogle ScholarPubMed
Cooper, DJ, Rosenfeld, J V, Murray, L, et al. Decompressive Craniectomy in Diffuse Traumatic Brain Injury. N. Engl. J. Med. 2011;364:1493–502. https://doi.org/10.1056/NEJMoa1102077.CrossRefGoogle ScholarPubMed
Hutchinson, PJ, Kolias, AG, Timofeev, IS, et al. Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension. N. Engl. J. Med. 2016;375:1119–30. https://doi.org/10.1056/NEJMOA1605215/SUPPL_FILE/NEJMOA1605215_DISCLOSURES.PDF.CrossRefGoogle ScholarPubMed
Khellaf, A, Khan, DZ, Helmy, A. Recent Advances in Traumatic Brain Injury. J. Neurol. 2019;266:2878–89. https://doi.org/10.1007/S00415-019-09541-4.CrossRefGoogle ScholarPubMed
Yang, MT. Multimodal Neurocritical Monitoring. Biomed. J. 2020;43:226–30. https://doi.org/10.1016/J.BJ.2020.05.005.CrossRefGoogle ScholarPubMed
Tas, J, Beqiri, E, van Kaam, CR, et al. An Update on the COGiTATE Phase II Study: Feasibility and Safety of Targeting an Optimal Cerebral Perfusion Pressure as a Patient-Tailored Therapy in Severe Traumatic Brain Injury. Acta Neurochir. Suppl. 2021;131:143–7. https://doi.org/10.1007/978-3-030-59436-7_29.Google ScholarPubMed
Hays, LMC, Udy, A, Adamides, AA, et al. Effects of Brain Tissue Oxygen (PbtO2) Guided Management on Patient Outcomes Following Severe Traumatic Brain Injury: A Systematic Review and Meta-analysis. J. Clin. Neurosci. 2022;99:349–58. https://doi.org/10.1016/J.JOCN.2022.03.017.CrossRefGoogle ScholarPubMed
Payen, JF, Launey, Y, Chabanne, R, et al. Intracranial Pressure Monitoring with and without Brain Tissue Oxygen Pressure Monitoring for Severe Traumatic Brain Injury in France (OXY-TC): An Open-Label, Randomised Controlled Superiority Trial. Lancet Neurol. 2023;22:1005–14. https://doi.org/10.1016/S1474-4422(23)00290-9.CrossRefGoogle ScholarPubMed
Timofeev, I, Carpenter, KLH, Nortje, J, et al. Cerebral Extracellular Chemistry and Outcome Following Traumatic Brain Injury: A Microdialysis Study of 223 Patients. Brain 2011;134:484–94. https://doi.org/10.1093/BRAIN/AWQ353.CrossRefGoogle ScholarPubMed

Save element to Kindle

To save this element to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Management of Moderate or Severe Traumatic Brain Injury
Available formats
×

Save element to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Management of Moderate or Severe Traumatic Brain Injury
Available formats
×

Save element to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Management of Moderate or Severe Traumatic Brain Injury
Available formats
×