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The effects of seven-strain probiotic supplementation on cell adhesion molecules, oxidative stress and antioxidant parameters in patients with traumatic brain injury: a randomised controlled clinical trial

Published online by Cambridge University Press:  23 January 2025

Nooshin Noshadi ,
Seyede Sana Sabet ,
Sarvin Sanaie ,
Ata Mahmoodpoor ,
Helda Tutunchi ,
Sina Naghshi Open the ORCID record for Sina Naghshi [Opens in a new window] ,
Seyed Rafie Arefhosseini  and
Mehrangiz Ebrahimi-Mameghani Open the ORCID record for Mehrangiz Ebrahimi-Mameghani [Opens in a new window]
Nooshin Noshadi
Affiliation:
Student Research Committee, Department of Clinical Nutrition, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Science, Tabriz, Iran
Seyede Sana Sabet
Affiliation:
Student Research Committee, Department of Clinical Nutrition, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Science, Tabriz, Iran
Sarvin Sanaie
Affiliation:
Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
Ata Mahmoodpoor
Affiliation:
Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
Helda Tutunchi
Affiliation:
Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Sina Naghshi
Affiliation:
Student Research Committee, Department of Clinical Nutrition, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Science, Tabriz, Iran
Seyed Rafie Arefhosseini
Affiliation:
Department of Biochemistry and Diet Therapy, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Mehrangiz Ebrahimi-Mameghani*
Affiliation:
Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Science, Tabriz, Iran
*
Corresponding author: Mehrangiz Ebrahimi-Mameghani; Email: ebrahimimamagani@tbzmed.ac.ir
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Abstract

The therapeutic effects of probiotics in patients with traumatic brain injury (TBI) remain unclear. This study aimed to investigate the effects of probiotic supplementation on cell adhesion molecules (CAMs), oxidative stress and antioxidant parameters in TBI patients. This randomised, double-blind, placebo-controlled trial included forty-six TBI patients who were randomly assigned to receive either a probiotic supplement (n 23) or a placebo (n 23) for 14 d. The probiotic capsule contained four strains of Lactobacillus (L. casei, L. bulgaricus, L. rhamnosus, L. acidophilus), two strains of Bifidobacterium (B. longum, B. breve) and Streptococcus thermophilus. Serum levels of intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, pro-oxidant–antioxidant balance (PAB), malondialdehyde (MDA), nitric oxide (NO), total antioxidant capacity (TAC) and arylesterase (ARE) activity were measured at the beginning and end of the trial. Dietary intakes of patients were also recorded at the beginning and end of the trial. At the end of the study, there were no significant changes in ICAM-1, VCAM-1, PAB, MDA, NO, TAC and ARE levels. However, patients who received probiotic supplements had significantly increased dietary intakes of energy, macronutrients, vitamin E, Zn, Cu and Se compared with the placebo group. This study provides evidence that probiotic supplementation for 14 d in TBI patients has beneficial effects on dietary intake. However, it did not affect serum levels of CAMs, oxidative stress or antioxidant parameters. These findings should be considered preliminary, and further research is needed to evaluate long-term and clinical outcomes.

Keywords

ProbioticOxidative stressPro-oxidant–antioxidant balanceCell adhesion moleculesTraumatic brain injury

Information

Type
Research Article
Information
British Journal of Nutrition , Volume 133 , Issue 7 , 14 April 2025 , pp. 892 - 900
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Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

Nooshin Noshadi and Seyede Sana Sabet are equally involved in the current study.

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