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Effects of soya consumption on serum adiponectin and leptin levels: An umbrella review of meta-analyses based on randomised controlled trials

Published online by Cambridge University Press:  07 March 2025

Harikumar Pallathadka ,
Enwa Felix Oghenemaro ,
Bahaa Ibrahim Saeed ,
N. Esanmurodova ,
Roopashree R ,
Deepak Nathiya ,
Parjinder Kaur ,
M. Ravi Kumar ,
Muthena Kariem  and
Naher H. S.
Harikumar Pallathadka
Affiliation:
Manipur International University, Imphal, Manipur, India
Enwa Felix Oghenemaro
Affiliation:
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Delta State University, Abraka, Delta State, Nigeria
Bahaa Ibrahim Saeed*
Affiliation:
Medical Laboratory Techniques Department, College of Health and Medical Technology, University of Al-maarif, Anbar, Iraq
N. Esanmurodova*
Affiliation:
Tashkent Institute of Irrigation and Agricultural Mechanization Engineers, National Research University, Tashkent, Uzbekistan Western Caspian University, Scientific Researcher, Baku, Azerbaijan
Roopashree R
Affiliation:
Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India
Deepak Nathiya
Affiliation:
Department of Pharmacy Practice, NIMS Institute of Pharmacy, NIMS University, Rajasthan, Jaipur, India
Parjinder Kaur
Affiliation:
Chandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Mohali 140307, Punjab, India
M. Ravi Kumar
Affiliation:
Department of Basic Science & Humanities, Raghu Engineering College, Visakhapatnam, India
Muthena Kariem
Affiliation:
Department of Medical Analysis, Medical Laboratory Technique College, The Islamic University, Najaf, Iraq Department of Medical Analysis, Medical Laboratory Technique College, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq Department of Medical Analysis, Medical Laboratory Technique College, The Islamic University of Babylon, Babylon, Iraq
Naher H. S.
Affiliation:
Laboratories Techniques Department, College of Health and Medical Techniques, Al-Mustaqbal University, 51001, Babylon, Iraq
*
Corresponding authors: Bahaa Ibrahim Saeed; Email: bahaaalani10@uoa.edu.iq; N. Esanmurodova; Email: nilufar1289@gmail.com
Corresponding authors: Bahaa Ibrahim Saeed; Email: bahaaalani10@uoa.edu.iq; N. Esanmurodova; Email: nilufar1289@gmail.com
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Abstract

The therapeutic effects of soya consumption on adipokine concentrations have yielded inconsistent results in previous meta-analyses. This umbrella meta-analysis aims to investigate the impact of soya and its isoflavones on serum adiponectin and leptin levels in adults. We searched the Cochrane Central, Web of Science, PubMed and Scopus databases until October 10, 2024. The articles were restricted to those written in English. We included meta-analysis studies that evaluated the effects of soya and its isoflavones on levels of adiponectin and leptin and reported effect sizes (ES) and corresponding CI. Two independent reviewers screened all articles based on eligibility criteria and extracted the required data from the included meta-analyses. The meta-analysis was performed using a random-effects model in STATA software. Six meta-analyses of randomised controlled trials meeting the inclusion criteria were included in the current umbrella meta-analysis. The findings indicated that soya and its isoflavones did not have a significant effect on adiponectin (ES = 0·10; 95 % CI: −0·22, 0·41; P = 0·55; I2 = 51·8 %) and leptin (ES = −0·37; 95 % CI: −1·35, 0·61; P = 0·46; I2 = 71·2 %) concentrations. Subgroup analysis based on participants’ mean age, total sample size and duration was conducted. Results showed that the effect is not statistically significant in any of the subgroups. In conclusion, soya and its isoflavones could not improve the adipokines mentioned above. However, further high-quality research in different countries is required to substantiate these findings.

Keywords

SoyaAdiponectinLeptinUmbrella meta-analysisSystematic reviews
Type
Systematic Review and Meta-Analysis
Information
British Journal of Nutrition , Volume 133 , Special Issue 6 , 28 March 2025 , pp. 817 - 826
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Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society

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