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Incidence and Prevalence of Dementia Over the Life Course of Aging Men: The Manitoba Follow-Up Study

Published online by Cambridge University Press:  27 May 2025

Philip Donald St John ,
Carly Jill Scramstad  and
Robert Bruce Tate
Philip Donald St John*
Affiliation:
Section of Geriatric Medicine, Department of Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada Centre on Aging, University of Manitoba, Winnipeg, Canada
Carly Jill Scramstad
Affiliation:
Section of Neurology, Department of Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada
Robert Bruce Tate
Affiliation:
Centre on Aging, University of Manitoba, Winnipeg, Canada Dept of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada
*
Corresponding author: Philip Donald St John; Email: pstjohn@hsc.mb.ca
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Abstract

We report the age-specific incidence and prevalence of dementia and the cumulative lifetime risk of dementia in a prospective cohort study of men who qualified for air crew training in the Second World War. The time frame of the analyses was from 1948 to 2024. Of the 3983 participants, 3960 died, 7 were lost to follow-up and 570 were diagnosed with dementia. The incidence of dementia was low prior to the age of 80 but increased markedly with age thereafter. The prevalence of dementia was also very closely related to age. There was a high competing risk of death.

Résumé

RÉSUMÉ

Incidence et prévalence de la démence au cours du cycle de vie d’hommes vieillissants : l’étude de suivi du Manitoba

Dans le cadre d’une étude de cohorte prospective portant sur des hommes s’étant qualifiés pour une formation destinée aux équipages aériens pendant la Seconde Guerre mondiale, nous voulons présenter l’incidence et la prévalence de la démence en fonction de l’âge, ainsi que le risque cumulatif de démence au cours d’un cycle de vie. Les analyses ont porté sur la période allant de 1948 à 2024. Sur 3983 participants, 3960 sont décédés alors que 7, sensés faire l’objet d’un suivi, ont été perdus de vue et que 570 ont reçu un diagnostic de démence. À noter que l’incidence de la démence était faible avant l’âge de 80 ans, mais augmentait par la suite de façon notable avec l’âge. Qui plus est, la prévalence de la démence était également très étroitement liée à l’âge tandis que le risque concurrent de décès était élevé.

Keywords

Dementia Epidemiologycohort studyincidence Prevalence
Type
Brief Communication
Information
Canadian Journal of Neurological Sciences , First View , pp. 1 - 4
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation

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