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A New Face of Neuro-Sjögren’s Syndrome: Case Series

Published online by Cambridge University Press:  21 May 2025

Farsana Mustafa Open the ORCID record for Farsana Mustafa [Opens in a new window] ,
Ekamjot Singh ,
Elavarasi Arunmohzimaran Open the ORCID record for Elavarasi Arunmohzimaran [Opens in a new window] ,
Shailesh B. Gaikwad ,
Rajesh Kumar Singh Open the ORCID record for Rajesh Kumar Singh [Opens in a new window] ,
Animesh Das Open the ORCID record for Animesh Das [Opens in a new window] ,
Jasmine Parihar Open the ORCID record for Jasmine Parihar [Opens in a new window] ,
Uma Kumar ,
Manjari Tripathi  and
Deepti Vibha Open the ORCID record for Deepti Vibha [Opens in a new window]
Farsana Mustafa
Affiliation:
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
Ekamjot Singh
Affiliation:
Department of Neuroimaging and Intervention Neuroradiology, All India Institute of Medical Sciences, New Delhi, India
Elavarasi Arunmohzimaran
Affiliation:
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
Shailesh B. Gaikwad
Affiliation:
Department of Neuroimaging and Intervention Neuroradiology, All India Institute of Medical Sciences, New Delhi, India
Rajesh Kumar Singh
Affiliation:
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
Animesh Das
Affiliation:
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
Jasmine Parihar
Affiliation:
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
Uma Kumar
Affiliation:
Department of Rheumatology, All India Institute of Medical Sciences, New Delhi, India
Manjari Tripathi
Affiliation:
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
Deepti Vibha*
Affiliation:
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
*
Corresponding author: Deepti Vibha; Email: deeptivibha@gmail.com
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Abstract:

Neurological manifestations can precede the sicca symptoms in Sjögren’s syndrome. These patients may develop systemic features of Sjögren’s syndrome in the future. In such patients, early diagnosis and management can avoid morbidity. In this case series, we describe three patients who presented with lumbar and brachial plexopathy due to Sjögren’s syndrome. These patients tested positive for Ro and La autoantibodies and had a positive Schirmer test. All patients were initiated on immunomodulation therapy, with notable clinical improvement.

Résumé:

Résumé:

Le nouveau visage du syndrome de Sjögren associé à des manifestations neurologiques : série de cas.

Les manifestations neurologiques du syndrome de Sjögren peuvent précéder l’apparition des symptômes de sécheresse (sicca) et, en pareil cas, il est possible que les signes généraux de la maladie se développent plus tard. Alors, une pose précoce du diagnostic du syndrome et une mise en œuvre rapide du traitement peuvent éviter des états pathologiques chez les patients touchés. Il sera donc question, dans la série ici présentée, de trois patients qui ont consulté pour une plexopathie lombaire ou brachiale attribuable au syndrome de Sjögren. Les patients ont obtenu des résultats positifs au dépistage des anticorps antiRo et antiLa ainsi qu’au test de Schirmer. Un traitement d’immunomodulation a été amorcé et il s’en est suivi, dans les trois cas, une amélioration clinique notable.

Keywords

brachial plexopathySjögren’s syndromelumbar plexopathyNeuro-Sjögren’s syndromeneuropathy
Type
Brief Communication
Information
Canadian Journal of Neurological Sciences , First View , pp. 1 - 4
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation

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References

Rubin, DI. Brachial and lumbosacral plexopathies: a review. Clin Neurophysiol Pract. 2020;5:173–193.Google Scholar
Colaci, M, Cassone, G, Manfredi, A, Sebastiani, M, Giuggioli, D, Ferri, C. Neurologic complications associated with Sjögren’s disease: case reports and modern pathogenic dilemma. Case Rep Neurol Med. 2014;2014:1–11.Google Scholar
Bhagavan, SM, Ramaswamy, SB, Khakh, GS, Govindarajan, R. Brachial plexopathy with Sjögren syndrome. Clin Case Rep. 2019;7(5):973–975.Google Scholar
Le Goff, M, Cornec, D, Jousse-Joulin, S, et al. Comparison of 2002 AECG and 2016 ACR/EULAR classification criteria and added value of salivary gland ultrasonography in a patient cohort with suspected primary Sjögren’s syndrome. Arthritis Res Ther. 2017;19:1–10.Google Scholar
Tominaga, N, Iizuka, T, Kaneko, J, et al. Autoimmune brachial amyotrophic diplegia and sensory neuronopathy with Sjögren’s syndrome: a case report. J Neurol Sci. 2016;368:1–3.Google Scholar
Seeliger, T, Prenzler, NK, Gingele, S, et al. Neuro-Sjögren: peripheral neuropathy with limb weakness in Sjögren’s syndrome. Front Immunol. 2019;10:1600.Google Scholar
Mori, K, Iijima, M, Koike, H, et al. The wide spectrum of clinical manifestations in Sjögren’s syndrome-associated neuropathy. Brain. 2005;128(11):2518–2534.Google Scholar
Barsottini, OG, Moraes, MP, Fraiman, PH, et al. Sjogren’s syndrome: a neurological perspective. Arq Neuro-psiquiat. 2024;81:1077–1083.Google Scholar