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Maternal and neonatal micronutrient levels in newborns with CHD

Published online by Cambridge University Press:  23 January 2018

Dilek Dilli ,
Nazan Neslihan Doğan ,
Utku Arman Örün ,
Murat Koç ,
Ayşegül Zenciroğlu ,
Selmin Karademir  and
Hasan Akduman
Dilek Dilli*
Affiliation:
Department of Neonatology, Dr Sami Ulus Maternity and Children Research and Training Hospital, University of Health Sciences, Ankara, Turkey
Nazan Neslihan Doğan
Affiliation:
Department of Neonatology, Dr Sami Ulus Maternity and Children Research and Training Hospital, University of Health Sciences, Ankara, Turkey
Utku Arman Örün
Affiliation:
Department of Pediatric Cardiology, Dr Sami Ulus Maternity and Children Research and Training Hospital, University of Health Sciences, Ankara, Turkey
Murat Koç
Affiliation:
Department of Cardiovascular Surgery, Dr Sami Ulus Maternity and Children Research and Training Hospital, University of Health Sciences, Ankara, Turkey
Ayşegül Zenciroğlu
Affiliation:
Department of Neonatology, Dr Sami Ulus Maternity and Children Research and Training Hospital, University of Health Sciences, Ankara, Turkey
Selmin Karademir
Affiliation:
Department of Pediatric Cardiology, Dr Sami Ulus Maternity and Children Research and Training Hospital, University of Health Sciences, Ankara, Turkey
Hasan Akduman
Affiliation:
Department of Neonatology, Dr Sami Ulus Maternity and Children Research and Training Hospital, University of Health Sciences, Ankara, Turkey
*
Correspondence to: D. Dilli, Dr Sami Ulus Kadın Sağlığı, ÇocukSağlığı ve Hastalıkları, SUAM, Yenidoğan Kliniği, Sağlık Bilimleri Üniversitesi, Babürcaddesi, Ankara, Turkey. Tel: +00 90 312 906 3619; Fax: 400 90 312 305 6016; E-mail: dilekdilli2@yahoo.com
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Abstract

Objective

It is suggested that folic acid and/or multivitamins, taken periconceptionally, have a role in the prevention of many congenital anomalies. The aim of this study was to determine the serum micronutrient levels in mother–infant pairs with CHD compared with those with healthy newborns and their mothers.

Methods

Serum levels of folic acid, homocysteine, zinc, vitamin A, vitamin D, and vitamin B12 were measured from 108 newborns with CHD (study group) and 103 healthy newborns (control group). The mothers’ micronutrient levels were also measured simultaneously.

Results

When compared with healthy newborns, for both maternal and neonatal data, homocysteine and zinc levels were higher and vitamin D levels were lower in the study group. In multivariate analysis, only maternal high zinc levels were associated with CHD in the newborns (p=0.02, OR: 0.9, 95% CI 0.8–0.9). The results did not change when analysed for truncal anomalies including truncus arteriosus, tetralogy of Fallot, and d-transposition of great arteries. There were positive correlations between maternal and neonatal levels of micronutrients, except vitamin B12.

Conclusion

We thought that high homocysteine and zinc levels and low vitamin D levels in mother–infant pairs might have a role in the aetiopathogenesis of CHD. Large-scale, prospective studies are needed to clarify the role of micronutrients in CHDs.

Keywords

Folic acidhomocysteinezincvitamin Avitamin Dvitamin B12micronutrientCHD
Type
Original Articles
Information
Cardiology in the Young , Volume 28 , Issue 4 , April 2018 , pp. 523 - 529
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Copyright
© Cambridge University Press 2018 

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