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Successful use of ivabradine in a 10-year-old patient with graft failure after heart transplantation

Published online by Cambridge University Press:  22 July 2022

Yosuke Ogawa Open the ORCID record for Yosuke Ogawa [Opens in a new window] ,
Susumu Urata  and
Ryo Inuzuka Open the ORCID record for Ryo Inuzuka [Opens in a new window]
Yosuke Ogawa
Affiliation:
Department of Pediatrics, The University of Tokyo Hospital, Tokyo, Japan
Susumu Urata
Affiliation:
Department of Pediatrics, The University of Tokyo Hospital, Tokyo, Japan
Ryo Inuzuka*
Affiliation:
Department of Pediatrics, The University of Tokyo Hospital, Tokyo, Japan
*
Author for correspondence: R. Inuzuka, MD, PhD, Department of Pediatrics, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. Tel: +81-3-3815-5411. E-mail: inuzukatky@gmail.com
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Abstract

We encountered a paediatric case of graft failure due to antibody-mediated rejection after heart transplantation in which ivabradine was effective. Inappropriate sinus tachycardia in denervated transplanted hearts is a good indication for ivabradine administration as beta-blockers have a limited efficacy. To our knowledge, this is the first report on the effectiveness of ivabradine in a paediatric heart transplant rejection case.

Keywords

Ivabradinepaediatricsheart failureheart transplantationinappropriate sinus tachycardiadenervated hearts

Information

Type
Brief Report
Information
Cardiology in the Young , Volume 33 , Issue 4 , April 2023 , pp. 649 - 651
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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References

Colvin, MM, Cook, JL, Chang, P, et al. Antibody-mediated rejection in cardiac transplantation: emerging knowledge in diagnosis and management: a scientific statement from the American Heart Association. Circulation 2015; 131: 1608–1639.CrossRefGoogle ScholarPubMed
Koruth, JS, Lala, A, Pinney, S, Reddy, VY, Dukkipati, SR. The clinical use of ivabradine. J Am Coll Cardiol 2017; 70: 1777–1784.CrossRefGoogle ScholarPubMed
Borer, JS, Böhm, M, Ford, I, et al. Effect of ivabradine on recurrent hospitalization for worsening heart failure in patients with chronic systolic heart failure: the SHIFT study. Eur Heart J 2012; 33: 2813–2820.CrossRefGoogle ScholarPubMed
Bonnet, D, Berger, F, Jokinen, E, Kantor, PF, Daubeney, PEF. Ivabradine in children with dilated cardiomyopathy and symptomatic chronic heart failure. J Am Coll Cardiol 2017; 70: 1262–1272.CrossRefGoogle ScholarPubMed
Rivinius, R, Helmschrott, M, Rahm, AK, et al. Five-year results of heart rate control with ivabradine or metoprolol succinate in patients after heart transplantation. Clin Res Cardiol 2022; 111: 141–153.CrossRefGoogle ScholarPubMed
Fang, Y, Debunne, M, Vercauteren, M, et al. Heart rate reduction induced by the if current inhibitor ivabradine improves diastolic function and attenuates cardiac tissue hypoxia. J Cardiovasc Phamacol 2012; 59: 260–267.CrossRefGoogle ScholarPubMed
Izumida, T, Imamura, T, Nakamura, M, Fukuda, N, Kinugawa, K. How to consider target heart rate in patients with systolic heart failure. ESC Heart Fail 2020; 7: 3231–3234.CrossRefGoogle ScholarPubMed