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Homeless street children in Nepal: Use of allostatic load to assess the burden of childhood adversity

Published online by Cambridge University Press:  23 January 2008

Carol M. Worthman  and
Catherine Panter-Brick
Carol M. Worthman*
Affiliation:
Emory University
Catherine Panter-Brick
Affiliation:
Durham University
*
Address correspondence and reprint requests to: Carol M. Worthman, Department of Anthropology, Emory University, Atlanta, GA 30322; E-mail: worthman@emory.edu.
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Abstract

As challenges to child well-being through economic disadvantage, family disruption, and migration or displacement escalate world wide, the need for cross-culturally robust understanding of childhood adversity proportionately increases. Toward this end, developmental risk was assessed in four contrasting groups of 107 Nepali children ages 10–14 years that represent distinctive, common conditions in which contemporary children grow up. Relative cumulative burden (allostatic load) indexed by multiple dimensions of physical and psychosocial stress was ascertained among homeless street boys and three family-based groups, from poor urban squatter settlements, urban middle class, and a remote rural village. Biomarkers of stress and vulnerability to stress included growth status, salivary cortisol, antibodies to Epstein–Barr virus, acute phase inflammatory responses (alpha1-antichymotrypsin), and cardiovascular fitness and reactivity (flex heart rate and pressor response). Individual biomarkers of risk and allostatic load differed markedly among groups, were highest in villagers, and varied by components of allostatic load. Such data suggest a need for critical appraisal of homelessness and migration as a risk factor to youth, given prevailing local conditions such as rural poverty, and represents the only multidimensional study of childhood allostatic load and developmental risk in non-Western settings.

Type
Research Article
Information
Development and Psychopathology , Volume 20 , Issue 1 , Winter 2008 , pp. 233 - 255
Copyright
Copyright © Cambridge University Press 2008

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Footnotes

We thank Rachel Baker for long-term work with street children in Kathmandu, Allison Todd for participation in the fieldwork, Joy F. Stallings and Katrina Trivers for laboratory technical assistance, Daniel J. Hruschka for statistical support, Child Workers in Nepal for on-site support, and the Journal Reviewers and Editor for valuable critiques. Our special gratitude goes to the young people and families who participated in this research in Nepal. Funding was supplied by Durham University, Emory University Research Committee, the Russell Sage Foundation, and the Lowenstein Center for the Study of the Development and Prevention of the Disruptive Behavior Disorders.

References

Adelekan, D. A., Northrop-Clewes, C. A., Owa, J. A., Oyedeji, A. O., Owoeye, A. A., & Thurnham, D. I. (2003). Use of biomarkers of sub-clinical infection, nutrition and neonatal maturity to interpret plasma retinol in Nigerian neonates. British Journal of Nutrition, 90, 353–362.CrossRefGoogle ScholarPubMed
Baker, R. (1998). Runaway street children in Nepal: Social competence away from home. In Hutchby, I. & Moran-Ellis, J. M. (Eds.), Children and social competence: Arenas of action (pp. 46–63). London: Falmer Press.Google Scholar
Baker, R., & Panter-Brick, C. (2000). A comparative perspective on children's “careers” and abandonment in Nepal. In Panter-Brick, C. & Smith, M. T. (Eds.), Abandoned children (pp. 161–181). Cambridge: Cambridge University Press.Google Scholar
Baker, R., Panter-Brick, C., & Todd, A. (1996). Methods used in research with street children in Nepal. Childhood, 3, 171–193.CrossRefGoogle Scholar
Baker, R., Panter-Brick, C., & Todd, A. (1997). Homeless street boys in Nepal: Their demography and lifestyle. Journal of Comparative Family Studies, 28, 129–146.CrossRefGoogle Scholar
Battaglia, D. F., Brown, M. E., Krasa, H. B., Thrun, L. A., Viguié, C., & Karsch, F. J. (1998). Systemic challenge with endotoxin stimulates corticotropin-releasing hormone and arginine vasopressin secretion into hypophyseal portal blood: Coincidence with gonadotropin-releasing hormone suppression. Endocrinology, 139, 4175–4181.CrossRefGoogle ScholarPubMed
Boyce, W. T., Adams, S., Tschann, J. M., Cohen, F., Wara, D., & Gunnar, M. R. (1995). Adrenocortical and behavioral predictors of immune responses to starting school. Pediatric Research, 38, 1009–1017.CrossRefGoogle ScholarPubMed
Boyce, W. T., Chesney, M., Alkon, A., Tschann, J., Adams, S., Chesterman, B., et al. (1995). Psychobiologic reactivity to stress and childhood respiratory illnesses: Results of two prospective studies. Psychosomatic Medicine, 57, 411–422.CrossRefGoogle ScholarPubMed
Boyce, W. T., & Ellis, B. J. (2005). Biological sensitivity to context. I. An evolutionary-developmental theory of the origins and functions of stress reactivity. Development and Psychopathology, 17, 271–301.CrossRefGoogle ScholarPubMed
Boyce, W. T., Frank, E., Jensen, P. S., Kessler, R. C., Nelson, C. A., & Steinberg, L. (1998). Social context in developmental psychopathology: Recommendations for future research from the MacArthur Network on Psychopathology and Development. Development and Psychopathology, 10, 143–164.CrossRefGoogle ScholarPubMed
Boyce, W. T., & Jemerin, J. (1990). Psychobiological differences in childhood stress response. I. Patterns of illness and susceptibility. Journal of Developmental and Behavioral Pediatrics, 11, 86–94.CrossRefGoogle ScholarPubMed
Cacioppo, J. T. (1994). Social neuroscience: Autonomic, neuroendocrine, and immune responses to stress. Psychophysiology, 31, 113–128.CrossRefGoogle ScholarPubMed
Cacioppo, J. T., Berntson, G. G., Malarkey, W. B., Kiecolt-Glaser, J. K., Sheridan, J. F., Poehlmann, K. M., et al. (1998). Autonomic, neuroendocrine, and immune responses to psychological stress: The reactivity hypothesis. Annals of the New York Academy of Sciences, 840, 664–673.CrossRefGoogle ScholarPubMed
Cacioppo, J. T., Berntson, G. G., Sheridan, J. F., & McClintock, M. K. (2000). Multilevel integrative analyses of human behavior: Social neuroscience and the complementing nature of social and biological approaches. Psychological Bulletin, 126, 829–843.CrossRefGoogle ScholarPubMed
Cacioppo, J. T., Kiecolt-Glaser, J. K., Malarkey, W. B., Laskowski, B. F., Rozlog, L. A., Poehlmann, K. M., et al. (2002). Autonomic and glucocorticoid associations with the steady-state expression of latent Epstein–Barr virus. Hormones and Behavior, 42, 32–41.CrossRefGoogle ScholarPubMed
Cacioppo, J. T., Malarkey, W. B., Kiecolt-Glaser, J. K., Uchino, B. N., Sgoutas-Emch, S.A., Sheridan, J. F., et al. (1995). Heterogeneity in neuroendocrine and immune responses to brief psychological stressors as a function of autonomic cardiac activation. Psychosomatic Medicine, 57, 154–164.CrossRefGoogle ScholarPubMed
Central Bureau of Statistics. (1987). Population monograph of Nepal. Kathmandu: HMG of Nepal.Google Scholar
Chang, S. M., Walker, S. P., Grantham-McGregor, S. M., & Powell, C. A. (2002). Early childhood stunting and later behaviour and school achievement. Journal of Child Psychology & Psychiatry & Allied Disciplines, 43, 775–783.CrossRefGoogle ScholarPubMed
Cicchetti, D., & Walker, E. F. (2001). Stress and development: Biological and psychological consequences. Development and Psychopathology, 13, 413–418.CrossRefGoogle Scholar
Clark, P., Hindmarsh, P., Shiell, A., Law, C., Honour, J., & Barker, D. (1996). Size at birth and adrenocortical function in childhood. Clinical Endocrinology, 45, 721–726.CrossRefGoogle ScholarPubMed
Cohen, S., Frank, E., Doyle, W. J., Skoner, D. P., & Rabin, B. S. (1998). Types of stressors that increase susceptibility to the common cold in healthy adults. Health Psychology, 17, 214–223.CrossRefGoogle Scholar
Coplan, J. D., Smith, E. L. P., Altemus, M., Scharf, B. A., Owens, M. J., Nemeroff, C. B., et al. (2001). Variabile foraging demand rearing: Sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates. Biological Psychiatry, 50, 200–204.CrossRefGoogle Scholar
Costello, E. J., Compton, S. N., Keeler, G. P., & Angold, A. (2002). Relationships between poverty and psychopathology: A natural experiment. Journal of the American Meducal Association, 290, 2023–2029.CrossRefGoogle Scholar
Darnton-Hill, I., Nishida, C., & James, W. P. T. (2004). A life course approach to diet, nutrition and the prevention of chronic diseases. Public Health and Nutrition, 7, 101–121.CrossRefGoogle ScholarPubMed
Davey Smith, G. (1998). Adverse socioeconomic conditions in childhood and cause specific adult mortality: Prospective observational study. British Medical Journal, 316, 1631–1635.CrossRefGoogle Scholar
Davis, M., & Emory, E. (1995). Sex differences in neonatal stress reactivity. Child Development, 66, 14–27.CrossRefGoogle ScholarPubMed
De Bellis, M. D. (2002). Developmental traumatology: A contributory mechanism for alcohol and substance use disorders. Psychoneuroendocrinology, 27, 155–170.CrossRefGoogle ScholarPubMed
De la Barra, X. (1998). Poverty: The main cause of ill health in urban children. Health Education and Behavior, 25, 46–59.CrossRefGoogle ScholarPubMed
Desjarlais, R., Eisenberg, L., Good, B., & Kleinman, A. (1995). World mental health: Problems and priorities in low-income countries. New York: Oxford University Press.CrossRefGoogle Scholar
Dettling, A. C., Parker, S., Lane, S. K., Sebanc, A. M., & Gunnar, M. R. (2000). Quality of care and temperament determine whether cortisol levels rise over the day for children in full-day childcare. Psychoneuroendocrinology, 25, 819–836.CrossRefGoogle Scholar
Ellis, B. J., Essex, M. J., & Boyce, W. T. (2005). Biological sensitivity to context: II. Empirical explorations of an evolutionary–developmental theory. Development and Psychopathology, 17, 303–328.CrossRefGoogle ScholarPubMed
Eveleth, P., & Tanner, J. (1990). Worldwide variation in human growth. New York: Cambridge University Press.Google Scholar
Ezzati, M., Lopez, A. D., Rodgers, A., Vander Hoorn, S., Murray, C. J. L., & Comparative Risk Assessment Collaborating Group. (2002). Selected major risk factors and global and regional burden of disease. Lancet, 360, 1347–1360.CrossRefGoogle ScholarPubMed
Fazel, M., & Stein, A. (2002). The mental health of refugee children. Archives of Disease in Childhood, 87, 366–370.CrossRefGoogle ScholarPubMed
Fernald, L. C., & Grantham-McGregor, S. M. (1998). Stress response in school-age children who have been growth retarded since early childhood. American Journal of Clinical Nutrition, 68, 691–698.CrossRefGoogle ScholarPubMed
Fernald, L. C., & Grantham-McGregor, S. M. (2002). Growth retardation is associated with changes in the stress response system and behavior in school-aged Jamaican children. Journal of Nutrition, 32, 3674–3679.CrossRefGoogle Scholar
Fernald, L. C., Grantham-McGregor, S. M., Manandhar, D. S., & Costello, A. (2003). Salivary cortisol and heart rate in stunted and nonstunted Nepalese school children. European Journal of Clinical Nutrition, 57, 1458–1465.CrossRefGoogle ScholarPubMed
Flinn, M. V., & England, B. G. (1995). Childhood stress and family environment. Current Anthropology, 36, 854–866.CrossRefGoogle Scholar
Flinn, M. V., & England, B. G. (1997). Social economics of childhood glucocorticoid stress response and health. American Journal of Physical Anthropology, 102, 33–53.3.0.CO;2-E>CrossRefGoogle ScholarPubMed
Flinn, M. V., & England, B. G. (2003). Childhood stress: Endocrine and immune responses to psychosocial events. In Wilce, J. M. (Ed.), Social and cultural lives of immune systems (pp. 105–145). London: Routledge.Google Scholar
Flinn, M. V., Quinlan, R. J., Decker, S. A., Turner, M. T., & England, B. G. (1996). Male–female differences in effects of parental absence on glucocorticoid stress response. Human Nature, 7, 125–162.CrossRefGoogle ScholarPubMed
Glaser, R., Kiecolt-Glaser, J. K., Malarkey, W. B., & Sheridan, J. F. (1998). The influence of psychological stress on the immune response to vaccines. Annals of the New York Academy of Sciences, 840, 649–655.CrossRefGoogle ScholarPubMed
Glaser, R., Kutz, L. A., MacCallum, R. C., & Malarkey, W. B. (1995). Hormonal modulation of Epstein–Barr virus replication. Neuroendocrinology, 62, 356–361.CrossRefGoogle ScholarPubMed
Glaser, R., Rabin, B., Chesney, M., Cohen, S., & Natelson, B. (1999). Stress-induced immunomodulation: Implications for infectious diseases? Journal of the American Medical Association, 281, 2268–2270.CrossRefGoogle ScholarPubMed
Granger, D. A., Hood, K. E., Dreschel, N. A., Sergeant, E., & Likos, A. (2001). Developmental effects of early immune stress on aggressive, socially reactive, and inhibited behaviors. Development and Psychopathology, 13, 599–610.CrossRefGoogle ScholarPubMed
Granger, D. A., & Kivlinghan, K. T. (2003). Integrating biological, behavioral, and social levels of analysis in early child development: Progress, problems, and prospects. Child Development, 74, 1058–1063.CrossRefGoogle Scholar
Granger, D. A., Weisz, J. R., McCracken, J. T., Ikeda, S. C., & Douglas, P. (1996). Reciprocal influences among adrenocortical activation, psychosocial processes, and the behavioral adjustment of clinic-referred children. Child Development, 67, 3250–3262.CrossRefGoogle ScholarPubMed
Grantham-McGregor, S. M., & Fernald, L. C. (1999). Effects of health and nutrition on cognitive and behavioral development in children in the first three years of life. Part 1: Small for gestational age, breastfeeding and protein-energy malnutrition. Food and Nutrition Bulletin, 20, 53–75.CrossRefGoogle Scholar
Gunnar, M. R. (2000). Early adversity and the development of stress reactivity and regulation. In Nelson, C. E. (Ed.), The effects of early adversity on neurobehavioral development (pp. 163–200). Mahwah, NJ: Erlbaum.Google Scholar
Gunnar, M. R., & Donzella, B. (2002). Social regulation of cortisol levels in early human development. Psychoneuroendocrinology, 27, 199–220.CrossRefGoogle ScholarPubMed
Gunnar, M. R., Morison, S. J., Chisholm, K., & Schuder, M. (2001). Salivary cortisol levels in children adopted from Romanian orphanages. Development and Psychopathology, 13, 611–628.CrossRefGoogle ScholarPubMed
Gunnar, M. R., Porter, F. L., Wolf, C. M., Rigatuso, J., & Larson, M. C. (1995). Neonatal stress reactivity: Predictions to later emotional temperament. Child Development, 66, 1–13.CrossRefGoogle ScholarPubMed
Hart, J., Gunnar, M. R., & Cicchetti, D. (1996). Altered neuroendocrine activity in maltreated children related to symptoms of depression. Development and Psychopathology, 8, 201–214.CrossRefGoogle Scholar
Heim, C., & Nemeroff, C. B. (2001). The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies. Biological Psychiatry, 49, 1023–1039.CrossRefGoogle ScholarPubMed
Heim, C., & Nemeroff, C. B. (2002). Neurobiology of early life stress: Clinical studies. Seminars in Clinical Neuropsychiatry, 7, 147–159.CrossRefGoogle ScholarPubMed
Henle, W., & Henle, G. (1982). Epstein–Barr virus and infectious mononucleosis. In Glaser, R. & Gottlieb-Stematsky, T. (Eds.), Human herpesvirus infections: Clinical aspects (pp. 151–162). New York: Marcel Dekker.Google Scholar
Herbert, T. B., & Cohen, S. (1993). Stress and immunity in humans: A meta-analytic review. Psychosomatic Medicine, 55, 364–379.CrossRefGoogle Scholar
Higley, J., Thompson, W., Champoux, M., Goldman, D., Hasert, M., Kraemer, G., et al. (1993). Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (Macaca mulatta). Archives of General Psychiatry, 50, 615–623.CrossRefGoogle ScholarPubMed
Hirshfeld, D. R., Rosenbaum, J. F., Biederman, J., Bolduc, E. A., Faraone, S. V., Snidman, N., et al. (1992). Stable behavioral inhibition and its association with anxiety disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 31, 103–111.CrossRefGoogle ScholarPubMed
Hruschka, D. J., Kohrt, B. A., & Worthman, C. M. (2005). Estimating between- and within-individual variation in cortisol levels using multilevel models. Psychoneuroendocrinology, 30, 698–714.CrossRefGoogle ScholarPubMed
Jones, J. F., & Straus, S. E. (1987). Chronic Epstein–Barr virus infection. Annual Review of Medicine, 38, 195–209.CrossRefGoogle ScholarPubMed
Kagan, J., Reznick, J. S., & Snidman, M. (1987). The physiology and psychology of behavioral inhibition in children. Child Development, 58, 1459–1473.CrossRefGoogle ScholarPubMed
Kirschbaum, C., & Hellhammer, D. (1994). Salivary cortisol in psychoneuroendocrine research: Recent developments and applications. Psychoneuroendocrinology, 19, 313–333.CrossRefGoogle ScholarPubMed
Krieger, N. (Ed.). (2004). Embodying inequality: Epidemiologic perspectives. Amityville, NY: Baywood Publishing.Google Scholar
Lewis, M., & Ramsay, D. S. (1995). Developmental change in infants' responses to stress. Child Development, 66, 657–670.CrossRefGoogle ScholarPubMed
Li, H., Barnhart, H. X., Stein, A. D., & Martorell, R. (2003). Effects of early childhood supplementation on the educational achievement of women. Pediatrics, 112, 1156–1162.CrossRefGoogle ScholarPubMed
Lupien, S. J., King, S., Meaney, M. J., & McEwen, B. S. (2001). Can poverty get under your skin? Basal cortisol levels and cognitive function in children from low and high socioeconomic status. Development and Psychopathology, 13, 653–676.CrossRefGoogle ScholarPubMed
Luthar, S. S. (1999). Poverty and children's adjustment. Newbury Park, CA: Sage.CrossRefGoogle Scholar
McDade, T. W. (2002). Status incongruity in Samoan youth: A biocultural analysis of culture change, stress, and immune function. Medical Anthropology Quarterly, 16, 123–150.CrossRefGoogle ScholarPubMed
McDade, T. W. (2005). The ecologies of human immune function. Annual Review of Anthropology, 34, 495–521.CrossRefGoogle Scholar
McDade, T. W., Stallings, J. F., Angold, A., Costello, E. J., Burleson, M., Cacioppo, J. T., et al. (2000). Epstein–Barr virus antibodies in whole blood spots: A minimally invasive method for assessing an aspect of cell-mediated immunity. Psychosomatic Medicine, 62, 560–568.CrossRefGoogle ScholarPubMed
McEwen, B. S. (2000a). Allostasis and allostatic load: Implications for neuropsychopharmacology. Neuropsychopharmacology, 22, 108–124.CrossRefGoogle ScholarPubMed
McEwen, B. S. (2000b). The neurobiology of stress: From serendipity to clinical relevance. Brain Research, 886, 172–189.CrossRefGoogle ScholarPubMed
McEwen, B. S., & Wingfield, J. C. (2003). The concept of allostasis in biology and biomedicine. Hormones and Behavior, 43, 2–15.CrossRefGoogle ScholarPubMed
Meaney, M. J. (2001). Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annual Review of Neuroscience, 24, 1161–1192.CrossRefGoogle Scholar
Milman, A., Frongillo, E. A., de Onis, M., & Hwang, J. Y. (2005). Differential improvement among countries in child stunting is associated with long-term development and specific interventions. Journal of Nutrition, 135, 1415–1422.CrossRefGoogle ScholarPubMed
Panter-Brick, C. (1996). Seasonal and sex variation in physical activity levels among agro-pastoralists in Nepal. American Journal of Physical Anthropology, 100, 7–21.3.0.CO;2-Y>CrossRefGoogle ScholarPubMed
Panter-Brick, C. (2001). Street children and their peers: Perspectives on homeless, poverty and health. In Schwartzman, H. B. (Ed.), Children and anthropology: Perspectives for the twenty-first century (pp. 83–97). Westport, CT: Bergin & Garvey.Google Scholar
Panter-Brick, C. (2002). Street children, human rights, and public health: A critique and future directions. Annual Review of Anthropology, 31, 147–171.CrossRefGoogle Scholar
Panter-Brick, C., Lunn, P. G., Baker, R., & Todd, A. (2001). Elevated acute-phase protein in stunted Nepali children reporting low morbidity: Different rural and urban profiles. British Journal of Nutrition, 85, 1–8.CrossRefGoogle ScholarPubMed
Panter-Brick, C., & Pollard, T. M. (1999). Work and hormonal variation in subsistence and industrial contexts. In Panter-Brick, C. & Worthman, C. M. (Eds.), Hormones, health, and behavior: A socio-ecological and lifespan perspective (pp. 139–183). New York: Cambridge University Press.Google Scholar
Panter-Brick, C., Todd, A., & Baker, R. (1996). Growth status of homeless Nepali boys: Do they differ from rural and urban controls? Social Science and Medicine, 43, 441–451.CrossRefGoogle ScholarPubMed
Panter-Brick, C., Todd, A., Baker, R., & Worthman, C. M. (1996b). Comparative study of flex heart rate in three samples of Nepali boys. American Journal of Human Biology, 6, 653–660.3.0.CO;2-L>CrossRefGoogle Scholar
Pelletier, D. L., & Frongillo, E. A. (2003). Changes in child survival are strongly associated with changes in malnutrition in developing countries. Journal of Nutrition, 133, 107–119.CrossRefGoogle ScholarPubMed
Pollitt, E. (2000). A developmental view of the undernourished child: background and purpose of the study in Pangalengan, Indonesia. European Journal of Clinical Nutrition, 54(Suppl. 2), S2–S10.CrossRefGoogle Scholar
Porges, S. W., Doussard-Roosevelt, J. A., & Maita, A. K. (1994). Vagal tone and the physiological regulation of emotion. Monographs of the Society for Research in Child Development, 59, 250–283.CrossRefGoogle ScholarPubMed
Raff, H., Homar, P. J., & Burns, E. A. (2002). Comparison of two methods for measuring salivary cortisol. Clinical Chemistry, 48, 207–208.CrossRefGoogle ScholarPubMed
Raine, A. (2003). Effects of environmental enrichment at ages 3–5 years on schizotypal personality and antisocial behavior at ages 17 and 23 years. American Journal of Psychiatry, 160, 1627–1635.CrossRefGoogle Scholar
Raine, A., Venables, P. H., Dalais, C., Mellingen, K., Reynolds, C., & Mednick, S. A. (2001). Early educational and health enrichment at age 3–5 years is associated with increased autonomic and central nervous system arousal and orienting at age 11 years: Evidence from the Mauritius Child Health Project. Psychophysiology, 38, 254–266.CrossRefGoogle ScholarPubMed
Repetti, R. L., Taylor, S. E., & Seeman, T. E. (2002). Risky families: Family social environments and the mental and physical health of offspring. Psychological Bulletin, 128, 330–366.CrossRefGoogle ScholarPubMed
Rutter, M. (1999). Psychosocial adversity and child psychopathology. British Journal of Psychiatry, 174, 480–493.CrossRefGoogle ScholarPubMed
Saraceno, B. (2003). Caring for children and adolescents with mental disorders. Geneva: World Health Organisation.Google Scholar
Schneider, M. L., & Moore, C. F. (2000). Effect of prenatal stress on development: A nonhuman primate model. In Nelson, C. A. (Ed.), The effects of early adversity on neurobehavioral development (pp. 201–244). Mahwah, NJ: Erlbaum.Google Scholar
Schwartz, D. B., Granger, D. A., Susman, E. J., Gunnar, M. R., & Laird, B. (1998). Assessing salivary cortisol in studies of child development. Child Development, 69, 1503–1513.CrossRefGoogle ScholarPubMed
Seeman, T. E., & McEwen, B. S. (1996). Impact of social environment characteristics on neuroendocrine regulation. Psychosomatic Medicine, 58, 459–471.CrossRefGoogle ScholarPubMed
Seeman, T. E., McEwen, B. S., Rowe, J. W., & Singer, B. H. (2001). Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging. Proceedings of the National Academy of Sciences USA, 98, 4770–4775.CrossRefGoogle ScholarPubMed
Seeman, T. E., Singer, B. H., Rowe, J. W., Horwitz, R. I., & McEwen, B. S. (1997). Price of adaptation-allostatic load and its health consequences: MacArthur studies of successful aging. Archives of Internal Medicine, 157, 2259–2268.CrossRefGoogle Scholar
Suomi, S. (1991). Early stress and adult emotional reactivity in rhesus monkeys. In Bock, G. & Whelan, J. (Eds.), The childhood environment and adult disease (pp. 171–188). Chichester: Wiley.Google Scholar
Thompson, D., Milford-Ward, A., & Whicher, J. T. (1992). The value of acute phase protein measurements in clinical practice. Annals of Clinical Biochemistry, 29, 123–131.CrossRefGoogle ScholarPubMed
Tout, K., de Haan, M., Campbell, E. K., & Gunnar, M. R. (1998). Social behavior correlates of cortisol activity in child care: Gender differences and time-of-day effects. Child Development, 69, 1247–1262.Google ScholarPubMed
Uchino, B. M., Cacioppo, J. T., & Kiecolt-Glaser, J. K. (1996). The relationship between social support and physiological process: A review with emphasis on underlying mechanisms and implications for health. Psychological Bulletin, 119, 488–531.CrossRefGoogle ScholarPubMed
Ulijaszek, S. J. (1996). Long-term consequences of early environments on human growth: A developmental perspective. In Ulijaszek, S. J. (Ed.), Long-term consequences of early environment: Growth, development and the lifespan perspective (pp. 25–43). Cambridge: Cambridge University Press.Google Scholar
United Nations Fund for Population Activities. (1996). State of world population 1996. Changing places: Population, development and the urban future. New York: Author.Google Scholar
United Nations Fund for Population Activities. (2000). State of world population 2000. Lives together, worlds apart: Men and women in a time of change. New York: Author.Google Scholar
UNICEF. (2002). State of the world's children report 2003. New York: Oxford University Press.Google Scholar
UNICEF. (2004). Maternal mortality in 2000: Estimates developed by WHO, UNICEF and UNFPA. Geneva: World Health Organisation.Google Scholar
van Eck, M., Berkhof, H., Nicolson, N., & Sulon, J. (1996). The effects of perceived stress, traits, mood states, and stressful daily events on salivary cortisol. Psychosomatic Medicine, 58, 447–458.CrossRefGoogle ScholarPubMed
World Bank. (1993). World development report 1993: Investing in health. New York: Oxford University Press.Google Scholar
World Health Organisation. (1995). Physical status: The use and interpretation of anthropometry. Geneva: Author.Google Scholar
World Health Organisation. (2002). World health report 2002. Reducing risks, promoting healthy life. Geneva: Author.Google Scholar
Worthman, C.M., & Stallings, J. (1997). Hormone measures in finger-prick blood spot samples: New field methods for reproductive endocrinology. American Journal of Physical Anthropology, 103, 1–21.3.0.CO;2-V>CrossRefGoogle Scholar
Worthman, C. M. (1999). The epidemiology of human development. In Panter-Brick, C. & Worthman, C. M. (Eds.), Hormones, health, and behavior: A socio-ecological and lifespan perspective (pp. 47–104). Cambridge: Cambridge University Press.Google Scholar
Wüst, S., Federenko, I., Hellhammer, D., & Kirschbaum, C. (2000). Genetic factors, perceived chronic stress, and the free cortisol response to awakening. Psychoneuroendocrinology, 25, 707–720.CrossRefGoogle ScholarPubMed
Yehuda, R. (1999). Biological factors associated with susceptibility to posttraumatic stress disorder. Canadian Journal of Psychiatry, 44, 34–39.CrossRefGoogle ScholarPubMed
Yehuda, R., Teicher, M. H., Trestman, R. L., Levengood, R. A., & Siever, L. J. (1996). Cortisol regulation in posttraumatic stress disorder and major depression: A chronobiological analysis. Biological Psychiatry, 40, 79–88.CrossRefGoogle ScholarPubMed