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The incidence of infection with cytomegalovirus in a normal population: A serological study in Greater London

Published online by Cambridge University Press:  15 May 2009

H. Stern  and
S. D. Elek
H. Stern
Affiliation:
Department of Bacteriology, St George's Hospital Medical School, London S. W. 1
S. D. Elek
Affiliation:
Department of Bacteriology, St George's Hospital Medical School, London S. W. 1
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A serological study of cytomegalovirus infection in London shows it to be prevalent. Under 5 years of age only 4% of children have antibodies, but this increases to 15% by 10 years of age and 21% by 15 years. The maximum incidence of 54% is reached by 25–35 years, and this is maintained in the older age groups of the population. In two mixed day schools the incidence of infection was significantly lower than in a boarding school, suggesting that close prolonged contact is required for spread of infection.

Different strains of cytomegalovirus possess common group-specific complement-fixing antigens.

It is suggested that clinical disease caused by cytomegaloviruses is more frequent and more varied than previously believed, although diagnosis may be difficult without virological help.

Information

Type
Research Article
Information
Journal of Hygiene , Volume 63 , Issue 1 , March 1965 , pp. 79 - 87
Copyright
Copyright © Cambridge University Press 1965

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