Hostname: page-component-6bb9c88b65-s7dlb Total loading time: 0 Render date: 2025-07-24T20:02:27.224Z Has data issue: false hasContentIssue false
  • English
  • Français

Toxin A–Negative, Toxin B–Positive Clostridium difficile Infection Diagnosed by Polymerase Chain Reaction

Published online by Cambridge University Press:  02 January 2015

Ying Cheng ,
Pengcheng Du ,
Chen Chen ,
Shengkai Yan ,
Hongbing Jia ,
Jing Wang ,
Qirong Yan ,
Hanping Feng  and
Jinxing Lu
Ying Cheng
Affiliation:
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China State Key Laboratory for Infectious Disease Prevention and Control, Beijing, People's Republic of China
Pengcheng Du
Affiliation:
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China State Key Laboratory for Infectious Disease Prevention and Control, Beijing, People's Republic of China
Chen Chen
Affiliation:
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China State Key Laboratory for Infectious Disease Prevention and Control, Beijing, People's Republic of China
Shengkai Yan
Affiliation:
China-Japan Friendship Hospital, Beijing, People's Republic of China
Hongbing Jia
Affiliation:
China-Japan Friendship Hospital, Beijing, People's Republic of China
Jing Wang
Affiliation:
China-Japan Friendship Hospital, Beijing, People's Republic of China
Qirong Yan
Affiliation:
School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, People's Republic of China
Hanping Feng
Affiliation:
Division of Infectious Diseases, Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts
Jinxing Lu*
Affiliation:
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China State Key Laboratory for Infectious Disease Prevention and Control, Beijing, People's Republic of China
*
Department of Hospital Acquired Infection Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Street 155, Changping District, Beijing 102206, People's Republic of China (lujinxing@icdc.cn)
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Information

Type
Letters to the Editor
Information
Infection Control & Hospital Epidemiology , Volume 32 , Issue 5 , May 2011 , pp. 520 - 522
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2011

Footnotes

a

These authors contributed equally to this article

References

1. Crobach, MJ, Dekkers, OM, Wilcox, MH, et al. European Society of Clinical Microbiology and Infectious Diseases (ESCMID): data review and recommendations for diagnosing Clostridium difficile infection (CDI). Clin Microbiol Infect 2009;15(12):1053–1066.CrossRefGoogle ScholarPubMed
2. Goorhuis, A, Legaria, MC, van den Berg, RJ, et al. Application of multiple-locus variable-number tandem-repeat analysis to determine clonal spread of toxin A-negative Clostridium difficile in a general hospital in Buenos Aires, Argentina. Clin Microbiol Infect 2009;15:1080–1086.Google Scholar
3. van den Berg, RJ, Claas, EC, Oyib, DH, et al. Characterization of toxin A–negative, toxin B–positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping. J Clin Microbiol 2004; 42(3):1035–1041.Google Scholar
4. Gerding, DN. Global epidemiology of Clostridium difficile infection in 2010. Infect Control Hosp Epidemiol 2010;31(suppl 1):S32–S34.Google Scholar
5. Barbut, F, Lalande, V, Burghoffer, B, Thien, HV, Grimprel, E, Petit, JC. Prevalence and genetic characterization of toxin A variant strains of Clostridium difficile among adults and children with diarrhea in France. J Clin Microbiol 2002;40:2079–2083.Google Scholar
6. Kato, H, Kato, N, Watanabe, K, et al. Identification of toxin Anegative, toxin B-positive Clostridium difficile by PCR. J Clin Microbiol 1998;36:2178–2182.Google Scholar
7. Geric, B, Rupnik, M, Gerding, DN, Grabnar, M, Johnson, S. Distribution of Clostridium difficile variant toxinotypes and strains with binary toxin genes among clinical isolates in an American hospital. J Med Microbiol 2004;53(9):887–894.Google Scholar
8. Rupnik, M, Kato, N, Grabnar, M, Kato, H. New types of toxin Anegative, toxin B-positive strains among Clostridium difficile isolates from Asia. J Clin Microbiol 2003;41(3):1118–1125.CrossRefGoogle ScholarPubMed
9. Kato, H, Kato, N, Katow, S, Maegawa, T, Nakamura, S, Lyerly, DM. Deletions in the repeating sequences of the toxin A gene of toxin A-negative, toxin B-positive Clostridium difficile strains. FEMS Microbiol Lett 1999;175:197–203.Google Scholar