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TP53 mutation may underlie increasing incidence of external auditory canal carcinoma

Published online by Cambridge University Press:  11 November 2024

A. Pandya Open the ORCID record for A. Pandya [Opens in a new window] ,
D. Chandrasekharan Open the ORCID record for D. Chandrasekharan [Opens in a new window] ,
K. Suchak Open the ORCID record for K. Suchak [Opens in a new window]  and
J. S. Virk Open the ORCID record for J. S. Virk [Opens in a new window]
J. S. Virk
Affiliation:
Otolaryngology and Pathology Department, Royal London Hospital, Barts NHS Health Trust, London, UK
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Abstract

Background

Primary neoplasm of the external auditory canal has historically been documented to have a low incidence rate of between one and six per million internationally, with UK incidence yet to be officially cited.

Methods

Here, we report a rise in incidence at a single UK trust with seven carcinomas (six T4 external auditory canal squamous cell and one T4 basal cell) reported within an 18-month period. All tumours underwent next generation sequencing.

Results

The cases recorded represented a twofold rise in incidence in reference to international literature from a population-adjusted estimate of 0.5–3 cases for the catchment area to seven cases. All cases were treated with temporal bone resections (n = 7) and with post-operative radiotherapy in six cases. Tumour analysis showed all were TP53 mutant and human papilloma virus (HPV)/P16 negative.

Conclusion

We suggest chronic inflammation and genetic alterations as putative contributory factors in our case series and outline clinical strategies for timely detection of external auditory canal neoplasms.

Keywords

Epigeneticsexternal auditory canalneoplasmssquamous cell carcinomatp53 mutations

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , First View , pp. 1 - 6
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.

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Footnotes

Aashish Pandya takes responsibility for the integrity of the content of the paper

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