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Why we should be looking for earlobe creases in ENT. A systematic review and meta-analysis of diagonal earlobe crease and coronary artery disease

Published online by Cambridge University Press:  20 December 2021

J Curtis Open the ORCID record for J Curtis [Opens in a new window]  and
S Walford
J Curtis*
Affiliation:
Department of ENT, University Hospital Coventry and Warwickshire, Coventry, UK
S Walford
Affiliation:
Department of ENT, University Hospital Coventry and Warwickshire, Coventry, UK
*
Author for correspondence: Dr J Curtis, Department of ENT, University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UK E-mail: joncurtis101@gmail.com
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Abstract

Objective

The association between diagonal earlobe crease and cardiovascular disease has been known for several decades. This review investigated whether there is a significant association between the presence of a diagonal earlobe crease and coronary artery disease independent of other confounding factors.

Method

This study was a systematic review and meta-analysis of selected studies using the Preferred Reporting Items for Systematic Reviews and Meta-analyses checklist.

Results

This study included 12 studies in the pooled analysis with 2415 cases and 2545 controls. The study found that patients with diagonal earlobe crease have an increased (four times) likelihood of having coronary artery disease. In addition, despite some previous studies suggesting that diagonal earlobe crease was simply a result of age, all 10 of the included studies that looked at this found that the relationship between diagonal earlobe crease and coronary artery disease was independent of both age and other known cardiovascular risk factors.

Conclusion

Patients with diagonal earlobe crease appear to have an increased risk of coronary artery disease, and this may be higher for patients with bilateral diagonal earlobe crease.

Keywords

OtologyPinna

Information

Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 139 , Issue 3 , March 2025 , pp. 160 - 167
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr J Curtis takes responsibility for the integrity of the content of the paper

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