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Published online by Cambridge University Press: 21 May 2025
Chemical, biological, radiological, and nuclear (CBRN) incidents pose increasing transborder risks globally, necessitating enhanced health sector preparedness.
This study aimed to develop a comprehensive CBRN preparedness assessment tool (PAT), operational response guidelines (ORG), and tabletop simulation scenarios for the health sectors of the Middle East and North Africa (MENA) region.
A mixed-methods approach comprised a systematic review of the literature up to 2022 in English and French, modified expert interviews (MIM), and an online Delphi questionnaire. Content analysis was performed on interview data. Using R-Studio™, consensus metrics and artificial intelligence techniques, including natural language processing, sentiment analysis, and unsupervised machine learning (ML) clustering algorithms, were deployed for advanced data analysis across all phases.
The literature review identified 63 relevant studies illustrating various preparedness strategies. The MIM’s thematic analysis, reinforced by AI-driven content analysis, emphasized the need for stronger inter-regional cooperation facilitated by organizations such as WHO and standardized tabletop simulation training. A robust consensus was achieved on the proposed assessment tool and operational response guidelines. ML analysis identified distinct expert clusters, providing additional consensus perspectives.
The study emphasized the urgency for collaborative CBRN response strategies within MENA, valuing the innovative aspect of our suggested PAT, ORG, and simulation scenarios. This work advocates a dynamic, resilient approach to disaster medicine preparedness, which is crucial for regional security and global health resilience, especially in the MENA. It also highlights the significant role of AI analysis methods in enriching analytical outcomes in disaster medicine research and promoting data-informed preparedness strategies.