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Mechanisms of cooperativity and allosteric regulation in proteins

Published online by Cambridge University Press:  17 March 2009

M. F. Perutz
M. F. Perutz
Affiliation:
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
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AUosteric proteins control and coordinate chemical events in the living cell. When Monod conceived that idea he said that he had discovered the second secret of life. The first was the structure of DNA. The theory as published by Monod et al. (1963) was concerned chiefly with cooperativity and feedback inhibition of enzymes, such as the inhibition of threonine deaminase, the first enzyme in the pathway of the synthesis of isoleucine, by isoleucine, and its activation by valine. Two years later the theory was formalized by Monod et al. (1965).

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Research Article
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Quarterly Reviews of Biophysics , Volume 22 , Issue 2 , May 1989 , pp. 139 - 237
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Copyright © Cambridge University Press 1989

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