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Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial: commentary, author response

Published online by Cambridge University Press:  27 May 2025

Colleen Loo Open the ORCID record for Colleen Loo [Opens in a new window] ,
Angelo Alonzo ,
David Barton ,
Michael Berk ,
Mary Lou Chatterton Open the ORCID record for Mary Lou Chatterton [Opens in a new window] ,
Vanessa Dong ,
Veronica Gálvez ,
Natalie T. Mills Open the ORCID record for Natalie T. Mills [Opens in a new window] ,
Philip B. Mitchell Open the ORCID record for Philip B. Mitchell [Opens in a new window]  and
Shanthi Sarma
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Colleen Loo*
Affiliation:
Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, New South Wales, Australia; Black Dog Institute, Randwick, New South Wales, Australia; and George Institute for Global Health, Newtown, New South Wales, Australia
Angelo Alonzo
Affiliation:
Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, New South Wales, Australia; Black Dog Institute, Randwick, New South Wales, Australia; and The George Institute for Global Health, Barangaroo, New South Wales, Australia
David Barton
Affiliation:
Neurocentrix, South Carlton, Victoria, Australia
Michael Berk
Affiliation:
Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Barwon Health, Deakin University, Geelong, Australia
Mary Lou Chatterton
Affiliation:
School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Vanessa Dong
Affiliation:
Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, New South Wales, Australia; and Black Dog Institute, Randwick, New South Wales, Australia
Veronica Gálvez
Affiliation:
Department of Psychiatry and Mental Health, Hospital Universitari Parc Tauli, Sabadell, Spain; and Institut Investigacio I Innovacio Parc Tauli, Sabadell, Spain
Natalie T. Mills
Affiliation:
Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia
Philip B. Mitchell
Affiliation:
Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, New South Wales, Australia
Shanthi Sarma
Affiliation:
Mental Health and Specialist Services, Gold Coast Health, Bond University, Robina, Queensland, Australia
Andrew A. Somogyi
Affiliation:
Discipline of Pharmacology, School of Biomedicine, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia
Anthony Rodgers
Affiliation:
George Institute for Global Health, Barangaroo, New South Wales, Australia
*
Correspondence: Colleen Loo. Email: colleen.loo@unsw.edu.au
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Abstract

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Keywords

Ketamine/esketaminemajor depressive disorderclinical drug studiesneuroscienceaffective disorders
Type
Commentary
Information
The British Journal of Psychiatry , Volume 226 , Issue 5 , May 2025 , pp. 317 - 318
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Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of Royal College of Psychiatrists

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References

Joks, G, Su, S, King, J. Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): commentary, joks et al.. Br J Psychiatry 2024 (https://resolve.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/abs/efficacy-and-safety-of-a-4week-course-of-repeated-subcutaneous-ketamine-injections-for-treatmentresistant-depression-kads-study-commentary-joks-et-al/ECA661E0DB69EA284F9776A794244726).CrossRefGoogle ScholarPubMed
Loo, C, Glozier, N, Barton, D, Baune, BT, Mills, NT, Fitzgerald, P, et al. Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial. Br J Psychiatry 2023; 223: 533–41.CrossRefGoogle ScholarPubMed
UK ECT Review Group. Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet 2003; 361: 799–808.CrossRefGoogle Scholar
Rodgers, A, Bahceci, D, Davey, CG, Chatterton, ML, Glozier, N, Hopwood, M, et al. Ensuring the affordable becomes accessible-lessons from ketamine, a new treatment for severe depression. Aust N Z J Psychiatry 2024; 58: 109–16.CrossRefGoogle ScholarPubMed
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