The study examined positive and negative responses to volunteering (satisfaction with volunteering, perceived contribution to beneficiaries, and burnout) among 102 adolescents in Israel. The conceptual framework for explaining those responses was the ecological approach to the study of human development. In that context, the paper deals with the combined contribution of two ecological systems—the ontogenic system and the microsystem. The ontogenic system included sociodemographic variables (gender and religiosity), as well as empowerment resources. The microsystem included variables related to family context (parental volunteer activity and family support for volunteering), as well as to the context of volunteer activity (perceived rewards, difficulties with volunteering, and professional supervision). Sociodemographic variables and difficulties in relations with the provider organization predicted burnout, whereas rewards and professional supervision predicted satisfaction with volunteering. Empowerment contributed most to explaining volunteers’ perceived contribution to the beneficiaries of services.